Vagus Nerve Modulation Using Focused Pulsed Ultrasound: Potential Applications and Preliminary Observations in a Rat.
Vagus Nerve Modulation Using Focused Pulsed Ultrasound: Potential Applications and Preliminary Observations in a Rat.
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DOI：
10.1002/ima.22080
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发表时间：
2014-03-01
影响因子：
3.3
通讯作者：
Irazoqui, Pedro
中科院分区：
文献类型：
--
作者：
Juan, Eduardo J.;Gonzalez, Rafael;Albors, Gabriel;Ward, Matthew P.;Irazoqui, Pedro
利用聚焦超声波来调节神经结构，由于其在治疗神经系统疾病方面的潜力，最近引起了人们的兴趣。虽然有几篇论文关注超声神经调节在周围神经上的应用，但这些研究都没有在迷走神经上进行。我们对聚焦脉冲超声（FPUS）对长Evans大鼠左颈迷走神经传导的影响进行了初步观察。超声能量的频率为1.1 MHz，在空间峰值，时间平均强度范围为13.6至93.4 W/cm2。多数病例迷走神经受到抑制。初步研究结果表明，声强度与神经抑制程度成正比关系。
The use of focused ultrasonic waves to modulate neural structures has gained recent interest due to its potential in treating neurological disorders non-invasively. While several papers have focused on the use of ultrasound neuromodulation on peripheral nerves, none of these studies have been performed on the vagus nerve. We present preliminary observations on the effects of focused pulsed ultrasound (FPUS) on the conduction of the left cervical vagus nerve of a Long Evans rat. Ultrasound energy was applied at a frequency of 1.1 MHz, and at spatial-peak, temporal average intensities that ranged from 13.6 to 93.4 W/cm2. Vagus nerve inhibition was observed in most cases. Results of this preliminary study suggested that there is a proportional relationship between acoustic intensity and the level of nerve inhibition.
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