Memory T cell responses targeting the SARS coronavirus persist up to 11 years post-infection.
Memory T cell responses targeting the SARS coronavirus persist up to 11 years post-infection.
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DOI：
10.1016/j.vaccine.2016.02.063
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发表时间：
2016-04-12
期刊：
影响因子：
5.5
通讯作者：
Tan YJ
中科院分区：
文献类型：
--
作者：
Ng OW;Chia A;Tan AT;Jadi RS;Leong HN;Bertoletti A;Tan YJ
严重急性呼吸综合征(SARS)是由一种新的人类冠状病毒--SARS冠状病毒(SARS-CoV)引起的一种高传染性传染病，于2002年底首次出现。该病毒据信起源于蝙蝠，并通过果子狸等中间动物传播给人类。由于人畜共患病的SARS冠状病毒和类SARS冠状病毒(SL-CoV)在蝙蝠水库中持续存在，SARS冠状病毒的重新出现仍然是一个值得关注的问题。在这项研究中，对感染后9年和11年后的3名SARS康复者进行了SARS特异性T细胞的筛选，所有检测到的记忆T细胞反应都针对SARS-CoV结构蛋白。针对SARS冠状病毒膜蛋白(M)和核衣壳蛋白(N)的两种CD8+T细胞反应，通过测定它们的人类白细胞抗原(HLA)限制性和最小T细胞表位区域来表征。此外，这些反应被发现持续到感染后11年。这些CD8+T细胞对新出现的中东呼吸综合征冠状病毒(MERS-CoV)没有交叉反应。了解针对SARS恢复者病毒结构蛋白的SARS特异性细胞免疫的持久性对于SARS疫苗的设计和开发非常重要，目前尚不能获得这种疫苗。
Severe acute respiratory syndrome (SARS) is a highly contagious infectious disease which first emerged in late 2002, caused by a then novel human coronavirus, SARS coronavirus (SARS-CoV). The virus is believed to have originated from bats and transmitted to human through intermediate animals such as civet cats. The re-emergence of SARS-CoV remains a valid concern due to the continual persistence of zoonotic SARS-CoVs and SARS-like CoVs (SL-CoVs) in bat reservoirs. In this study, the screening for the presence of SARS-specific T cells in a cohort of three SARS-recovered individuals at 9 and 11 years post-infection was carried out, and all memory T cell responses detected target the SARS-CoV structural proteins. Two CD8+ T cell responses targeting the SARS-CoV membrane (M) and nucleocapsid (N) proteins were characterized by determining their HLA restriction and minimal T cell epitope regions. Furthermore, these responses were found to persist up to 11 years post-infection. An absence of cross-reactivity of these CD8+ T cell responses against the newly-emerged Middle East respiratory syndrome coronavirus (MERS-CoV) was also demonstrated. The knowledge of the persistence of SARS-specific celullar immunity targeting the viral structural proteins in SARS-recovered individuals is important in the design and development of SARS vaccines, which are currently unavailable.
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影响因子：
5
作者：
Cameron MJ;Bermejo-Martin JF;Danesh A;Muller MP;Kelvin DJ
通讯作者：
Kelvin DJ
DOI：
10.1016/j.clim.2006.05.002
发表时间：
2006-08
期刊：
Clinical immunology (Orlando, Fla.)
影响因子：
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通讯作者：
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通讯作者：
Fouchier RA
影响因子：
5.4
作者：
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通讯作者：
Perlman, Stanley
影响因子：
5.4
作者：
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通讯作者：
Subbarao, Kanta