Mechanisms of allergen-specific immunotherapy and immune tolerance to allergens.
Mechanisms of allergen-specific immunotherapy and immune tolerance to allergens.
复制标题
过敏原特异性免疫疗法的机制和对过敏原的免疫耐受性。
DOI：
10.1186/s40413-015-0063-2
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Akdis M
中科院分区：
文献类型：
--
作者：
Akdis CA;Akdis M
对变态反应、哮喘、自身免疫性疾病、肿瘤、器官移植和慢性感染的免疫调节机制的理解取得了实质性进展，导致了各种靶向治疗方法。过敏原特异性免疫疗法（AIT）作为过敏性疾病的脱敏疗法已经使用了100年，并且代表了潜在的治愈性和特异性治疗方式。过敏原-AIT具有其作用机制的机制包括非常早期的脱敏作用、调节T细胞和B细胞应答和相关抗体同种型以及抑制嗜酸性粒细胞、嗜碱性粒细胞和肥大细胞向组织的迁移和释放它们的介质。调节性T细胞（Treg）已被鉴定为对过敏原的外周耐受中的免疫过程的关键调节因子。过敏原特异性效应T细胞向调节表型的偏移似乎是对过敏原的健康免疫应答的发展和AIT成功结局的关键事件。天然存在的FoxP 3 + CD 4 + CD 25 + Treg细胞和可诱导的1型Treg（Tr 1）细胞以几种主要方式有助于控制变应原特异性免疫应答，其可以概括为抑制支持效应T细胞产生的树突状细胞;抑制效应Th 1、Th 2和Th 17细胞;抑制变应原特异性IgE和诱导IgG 4;抑制肥大细胞、嗜碱性粒细胞和嗜酸性粒细胞以及抑制效应T细胞向组织的迁移。免疫干预的新策略可能包括靶向过敏原耐受的分子机制以及效应和调节性T细胞亚群的相互调节。
Substantial progress in understanding mechanisms of immune regulation in allergy, asthma, autoimmune diseases, tumors, organ transplantation and chronic infections has led to a variety of targeted therapeutic approaches. Allergen-specific immunotherapy (AIT) has been used for 100 years as a desensitizing therapy for allergic diseases and represents the potentially curative and specific way of treatment. The mechanisms by which allergen-AIT has its mechanisms of action include the very early desensitization effects, modulation of T- and B-cell responses and related antibody isotypes as well as inhibition of migration of eosinophils, basophils and mast cells to tissues and release of their mediators. Regulatory T cells (Treg) have been identified as key regulators of immunological processes in peripheral tolerance to allergens. Skewing of allergen-specific effector T cells to a regulatory phenotype appears as a key event in the development of healthy immune response to allergens and successful outcome in AIT. Naturally occurring FoxP3+ CD4+CD25+ Treg cells and inducible type 1 Treg (Tr1) cells contribute to the control of allergen-specific immune responses in several major ways, which can be summarized as suppression of dendritic cells that support the generation of effector T cells; suppression of effector Th1, Th2 and Th17 cells; suppression of allergen-specific IgE, and induction of IgG4; suppression of mast cells, basophils and eosinophils and suppression of effector T cell migration to tissues. New strategies for immune intervention will likely include targeting of the molecular mechanisms of allergen tolerance and reciprocal regulation of effector and regulatory T cell subsets.
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DOI：
10.4168/aair.2011.3.1.11
发表时间：
2011-01
期刊：
Allergy, asthma & immunology research
影响因子：
--
作者：
Akkoc T;Akdis M;Akdis CA
通讯作者：
Akdis CA
影响因子：
14.2
作者：
Akdis, Muebeccel;Akdis, Cezmi A.
通讯作者：
Akdis, Cezmi A.
影响因子：
14.2
作者：
Akdis, Cezmi A.;Akdis, Muebeccel
通讯作者：
Akdis, Muebeccel
影响因子：
14.2
作者：
Akdis, Muebeccel;Burgler, Simone;Akdis, Cezmi A.
通讯作者：
Akdis, Cezmi A.
影响因子：
6.1
作者：
Alexander, C;Ying, S;Larché, M
通讯作者：
Larché, M