Behavioral dissociations between C57BL/6 and DBA/2 mice on learning and memory tasks: A hippocampal-dysfunction hypothesis
Behavioral dissociations between C57BL/6 and DBA/2 mice on learning and memory tasks: A hippocampal-dysfunction hypothesis
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C57BL/6 和 DBA/2 小鼠在学习和记忆任务上的行为分离：海马功能障碍假设
DOI：
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发表时间：
1993
期刊：
影响因子：
--
通讯作者：
J. Wehner
中科院分区：
文献类型：
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作者：
R. Paylor;Linda Baskall;J. Wehner
我们最近证明，C57BL/6 (C57) 小鼠能够在莫里斯水任务中进行空间学习，而 DBA/2 (DBA) 小鼠则受到损害。 DBA 小鼠在 Morris 任务中受损可能有多种原因。本研究的主要目的是了解 DBA 损伤的本质。首先，我们证明 DBA 小鼠没有一般的学习障碍，因为它们可以解决两个不同的辨别问题。使用充满水的十字迷宫和莫里斯任务的修改版本，我们表明 DBA 小鼠可以（1）看到远端线索，（2）关注迷宫外环境，以及（3）如果训练允许它们仅利用部分远端环境，则可以了解隐藏平台的位置。然而，探测数据表明，与 C57 小鼠相比，DBA 小鼠并不能形成迷宫外环境的完整表征。最终实验表明，DBA 小鼠在需要条件学习的任务上也受到损害，但在反应倾向任务和非条件学习任务上的表现与 C57 小鼠一样好。这些研究和其他研究的结果表明，DBA 小鼠的学习和记忆过程可能因海马功能受损而受到干扰。
We recently demonstrated that C57BL/6 (C57) mice are capable of spatial learning in the Morris water task whereas DBA/2 (DBA) mice are impaired. There may be a number of reasons why the DBA mice are impaired in the Morris task. The main objective of this study was to understand the nature of the DBA impairment. First, we showed that DBA mice do not have a general learning impairment, since they can solve two different discrimination problems. Using a water-filled plus maze and a modified version of the Morris task, we showed that DBA mice can (1) see distal cues, (2) attend to the extramaze environment, and (3) learn the place of a hidden platform if training allows them to utilize only part of the distal environment. Probe data indicate, however, that in contrast to C57 mice, DBA mice do not form a complete representation of the extra-maze environment. Final experiments demonstrate that DBA mice are also impaired on a task that requires conditional learning but perform as well as C57 mice on a response-tendency task and a nonconditional learning task. The results of these and other studies suggest that learning and memory processes in DBA mice may be disrupted as a result of impaired hippocampal function.
影响因子：
56.9
作者：
COHEN, NJ;SQUIRE, LR
通讯作者：
SQUIRE, LR
四种小鼠品系中尼古丁诱导的耐受性和受体变化。
DOI：
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发表时间：
1986
期刊：
The Journal of pharmacology and experimental therapeutics
影响因子：
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作者：
Marks,MJ;Romm,E;Gaffney,DK;Collins,AC
通讯作者：
Collins,AC