Distinct cortical and subcortical predictors of Purdue Pegboard decline in Parkinson's disease and atypical parkinsonism.
Distinct cortical and subcortical predictors of Purdue Pegboard decline in Parkinson's disease and atypical parkinsonism.
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DOI：
10.1038/s41531-023-00521-0
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发表时间：
2023-06-05
影响因子：
8.7
通讯作者：
Vaillancourt, David E.
中科院分区：
文献类型：
--
作者：
Wilkes, Bradley J.;Tobin, Emily R.;Arpin, David J.;Wang, Wei-en;Okun, Michael S.;Jaffee, Michael S.;McFarland, Nikolaus R.;Corcos, Daniel M.;Vaillancourt, David E.
帕金森病（PD）和非典型帕金森病的研究迫切需要疾病进展的客观测量，但可能会受到实用性和成本的阻碍。普渡大学钉板测试（PPT）客观、重测可靠性高、成本低。本研究的目标是确定：(1) PD、非典型帕金森症患者和健康对照的多部位队列中 PPT 的纵向变化； （2）PPT表现是否反映了神经影像学揭示的大脑病理学； (3) 量化 PD 患者在 PPT 期间表现出的运动缺陷。帕金森病患者表现出 PPT 表现下降，这与运动症状进展相关，而对照组则未发现这种情况。基底神经节的神经影像学测量是 PD PPT 表现的重要预测因子，而皮质、基底神经节和小脑区域是非典型帕金森病的预测因子。部分 PD 患者的加速度测量显示加速度范围缩小且加速度模式不规则，这与 PPT 评分相关。
Objective measures of disease progression are critically needed in research on Parkinson’s disease (PD) and atypical Parkinsonism but may be hindered by both practicality and cost. The Purdue Pegboard Test (PPT) is objective, has high test-retest reliability, and has a low cost. The goals of this study were to determine: (1) longitudinal changes in PPT in a multisite cohort of patients with PD, atypical Parkinsonism, and healthy controls; (2) whether PPT performance reflects brain pathology revealed by neuroimaging; (3) quantify kinematic deficits shown by PD patients during PPT. Parkinsonian patients showed a decline in PPT performance that correlated with motor symptom progression, which was not seen in controls. Neuroimaging measures from basal ganglia were significant predictors of PPT performance in PD, whereas cortical, basal ganglia, and cerebellar regions were predictors for atypical Parkinsonism. Accelerometry in a subset of PD patients showed a diminished range of acceleration and irregular patterns of acceleration, which correlated with PPT scores.
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DOI：
10.1002/mds.28312
发表时间：
2021-01
期刊：
Movement disorders : official journal of the Movement Disorder Society
影响因子：
--
作者：
Iwaki H;Blauwendraat C;Leonard HL;Makarious MB;Kim JJ;Liu G;Maple-Grødem J;Corvol JC;Pihlstrøm L;van Nimwegen M;Smolensky L;Amondikar N;Hutten SJ;Frasier M;Nguyen KH;Rick J;Eberly S;Faghri F;Auinger P;Scott KM;Wijeyekoon R;Van Deerlin VM;Hernandez DG;Gibbs RJ;Day-Williams AG;Brice A;Alves G;Noyce AJ;Tysnes OB;Evans JR;Breen DP;Estrada K;Wegel CE;Danjou F;Simon DK;Andreassen OA;Ravina B;Toft M;Heutink P;Bloem BR;Weintraub D;Barker RA;Williams-Gray CH;van de Warrenburg BP;Van Hilten JJ;Scherzer CR;Singleton AB;Nalls MA
通讯作者：
Nalls MA
影响因子：
4
作者：
Hinkle JT;Pontone GM
通讯作者：
Pontone GM
DOI：
10.1093/brain/awx146
发表时间：
2017-08-01
期刊：
Brain : a journal of neurology
影响因子：
--
作者：
Burciu RG;Ofori E;Archer DB;Wu SS;Pasternak O;McFarland NR;Okun MS;Vaillancourt DE
通讯作者：
Vaillancourt DE
影响因子：
3.7
作者：
Archer, Derek B.;Vaillancourt, David E.;Coombes, Stephen A.
通讯作者：
Coombes, Stephen A.
影响因子：
4.1
作者：
Hattori, Nobutaka;Takeda, Atsushi;Takahashi, Ryosuke
通讯作者：
Takahashi, Ryosuke