Psychomotor processing and functional decline in Parkinson's disease predicted by the Purdue Pegboard test.
Psychomotor processing and functional decline in Parkinson's disease predicted by the Purdue Pegboard test.
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DOI：
10.1002/gps.5492
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发表时间：
2021-06
影响因子：
4
通讯作者：
Pontone GM
中科院分区：
文献类型：
--
作者：
Hinkle JT;Pontone GM
普渡钉板测试（PPT）评估上肢灵活性和运动技能。我们假设PPT技能可以预测帕金森病（PD）患者的功能和认知下降，而不依赖于运动障碍的分级指标。我们使用了399名参加Deprenyl和生育酚抗氧化治疗帕金森病（DATATOP）试验的PD参与者的数据。提取统一帕金森病评定量表（UMRS）指标、神经心理学评估和临床评定量表，采用多变量线性混合效应（LME）和广义估计方程（GEE）回归模型进行分析。在多变量logistic回归中，较高的基线和随时间变化的PPT评分预测在整个纵向随访中更好的视觉处理速度和注意力。在记忆力、非视觉注意力、音素流畅性或定势转换测试中，没有发现类似的强关联。PPT表现独立于运动功能障碍（运动功能障碍量表第三部分），与运动功能障碍量表第二部分测量的日常生活活动（ADL）功能变化显著相关。低基线PPT评分（≤第10百分位数）使后期ADL功能障碍的相对风险增加一倍（≥第90百分位数）。PPT损伤选择性地预测PD中精神运动处理速度的下降。这种关联的领域特异性可能反映了自上而下的视觉和运动控制通路的相关病理生理变化。PPT还预测在调整运动障碍的客观测量后ADL功能障碍的增加。我们认为，PPT评分可能是预测认知变化和ADL功能障碍，这对病人和照顾者的生活质量有显着的影响，在临床上有用。此外，简单的基于任务的评估，如PPT，可用于PD的远程评估。
The Purdue Pegboard test (PPT) assesses upper-extremity dexterity and motor skills. We hypothesized that PPT skill would predict functional and cognitive decline in Parkinson’s disease (PD), independent of observer-rated measures of motor impairment. We utilized data from 399 PD participants enrolled in the Deprenyl and Tocopherol Antioxidative Therapy of Parkinsonism (DATATOP) trial. Unified Parkinson Disease Rating Scale (UPDRS) metrics, neuropsychological assessments, and clinical rating scales were extracted for analysis with multivariate linear mixed-effects (LME) and generalized estimating equation (GEE) regression models. In multivariate logistic regression, higher baseline and time-varying PPT scores predicted better visual processing speed and attention throughout longitudinal follow-up. No similarly strong associations were found for tests of memory, non-visual attention, phonemic fluency, or set-shifting. Independently of observer-rated motor impairment (UPDRS part III), PPT performance was significantly associated with changes in activities of daily living (ADL) function measured with UPDRS part II. Low baseline PPT score (≤10th percentile) doubled the relative risk of later ADL dysfunction (≥90th percentile). PPT impairment selectively predicted declining psychomotor processing speed in PD. The domain-specificity of this association may reflect correlated pathophysiological changes in top-down visual and motor control pathways. PPT also predicted increasing ADL dysfunction after adjusting for objective measures of motor impairment. We suggest that PPT scores may be prognostically useful for predicting cognitive changes and ADL dysfunction, which have dramatic impacts on both patient and caregiver quality of life. Furthermore, simple task-based assessments like the PPT could be investigated for remote assessment in PD.
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影响因子：
5.7
作者：
Silva, P. H. R.;Spedo, C. T.;Leoni, R. F.
通讯作者：
Leoni, R. F.
影响因子：
11.2
作者：
Shoulson, I
通讯作者：
Shoulson, I
影响因子：
8.6
作者：
Berg, Daniela;Postuma, Ronald B.;Bloem, Bastiaan;Chan, Piu;Dubois, Bruno;Gasser, Thomas;Goetz, Christopher G.;Halliday, Glenda M.;Hardy, John;Lang, Anthony E.;Litvan, Irene;Marek, Kenneth;Obeso, Jose;Oertel, Wolfgang;Olanow, C. Warren;Poewe, Werner;Stern, Matthew;Deuschl, Guenther
通讯作者：
Deuschl, Guenther
影响因子：
81.5
作者：
Poewe, Werner;Seppi, Klaus;Lang, Anthony E.
通讯作者：
Lang, Anthony E.
DOI：
10.1111/j.1532-5415.2000.tb06891.x
发表时间：
2000-08-01
影响因子：
6.3
作者：
Aarsland, D;Larsen, JP;Laake, K
通讯作者：
Laake, K