CRP Stimulates GDF15 Expression in Endothelial Cells through p53.
CRP Stimulates GDF15 Expression in Endothelial Cells through p53.
复制标题
DOI：
10.1155/2018/8278039
复制
发表时间：
2018
影响因子：
4.6
通讯作者：
Evans MK
中科院分区：
文献类型：
--
作者：
Kim Y;Noren Hooten N;Evans MK
Growth differentiation factor 15 (GDF15) is a multifunctional, secreted protein that is a direct target gene of p53. GDF15 is a prospective biomarker of cardiovascular disease (CVD). C-reactive protein (CRP), like GDF15, is implicated in inflammation and an independent biomarker of CVD. However, the molecular interactions between GDF15 and CRP remain unexplored. In women, we found a significant relationship between hsCRP and GDF15 serum and mRNA levels. In vitro treatment of cultured human aortic endothelial cells (HAECs) with purified CRP or transfection of a CRP plasmid into HAECs induced GDF15 expression. Dual-luciferase reporter assays confirmed that CRP significantly increased the levels of GDF15 promoter luciferase activity, indicating that CRP induces GDF15 transcription. Chromatin immunoprecipitation (ChIP) assays confirmed that p53 was recruited to both p53 binding sites 1 and 2 in the GDF15 promoter in response to CRP. We have uncovered a linkage between CRP and GDF15, a new clue that could be important in the pathogenesis of endothelial inflammation.
登录
查看更多内容
影响因子：
82.9
作者：
Emmerson, Paul J.;Wang, Feng;Wu, Xinle
通讯作者：
Wu, Xinle
DOI：
10.1016/j.bbrc.2011.06.016
发表时间：
2011-07-08
影响因子：
3.1
作者：
Choi, Ji-Won;Lee, Kyung Hye;Chung, Ji Hyung
通讯作者：
Chung, Ji Hyung
影响因子：
20.1
作者：
Kempf, T;Eden, M;Wollert, KC
通讯作者：
Wollert, KC
影响因子：
--
作者：
Kempf, Tibor;Sinning, Jan-Malte;Wollert, Kai C.
通讯作者：
Wollert, Kai C.
影响因子：
4.8
作者：
Ding, Qi;Mracek, Tomas;Bing, Chen
通讯作者：
Bing, Chen