Air pollution and respiratory health among diabetic and non-diabetic subjects in Pune, India—results from the Wellcome Trust Genetic Study
Air pollution and respiratory health among diabetic and non-diabetic subjects in Pune, India—results from the Wellcome Trust Genetic Study
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印度浦那糖尿病和非糖尿病受试者的空气污染和呼吸系统健康——来自 Wellcome Trust 基因研究的结果
DOI：
10.1007/s11356-017-9148-5
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发表时间：
2017
影响因子：
5.8
通讯作者：
S. Gore
中科院分区：
文献类型：
--
作者：
M. Khafaie;S. Salvi;C. Yajnik;Ajay R. Ojha;B. Khafaie;S. Gore
糖尿病患者可能比健康人更容易受到环境空气污染物的有害影响。但是，导致糖尿病患者易受空气污染影响的风险因素尚未确定。我们研究了暴露于环境PM10对糖尿病和非糖尿病受试者的慢性症状和肺功能测试（PFT）的影响。此外，为了研究易感性的可能决定因素，我们招募了400名2型糖尿病患者和465名健康受试者，他们被调查了慢性呼吸道症状（CRS），然后根据标准方案进行了用力肺活量（FVC）和用力呼气容积1（FEV 1）的测量。计算每例受试者的预计FEV 1和FVC百分比（分别为FEV1%和FVC%）。采用AERMOD弥散模型估算受试者居住地的颗粒物（PM10）浓度。使用逻辑回归探讨PM10和CRS之间的关联。我们还使用控制潜在混杂因素的线性回归模型来研究长期暴露于PM10与FEV1%和FVC%之间的关系。糖尿病患者当前喘息、过敏症状、胸闷、FEV 1/FVC <70%、医生诊断为哮喘和COPD的患病率显著高于非糖尿病患者。糖尿病组与非糖尿病组PFT百分比预测值差异无统计学意义（P < 0.05）。我们估计PM10浓度增加1 SD与呼吸困难风险增加1.50倍相关（95% CI，1.12-2.01）。PM10浓度较高的暴露也与FVC%较低显著相关。PM10浓度增加1 SD μg/m3（=98.38）的效应大小为FVC%降低3.71%（95% CI，0.48-4.99）。此外，我们指出，这些关联的强度在超重，吸烟者和老年人中更高。我们证明了空气污染对肺功能降低的可能贡献，而与糖尿病状态无关。这项研究表明，减少暴露可能会显着减少疾病的表现，如呼吸困难和肺功能受损。我们认为，较高的BMI、吸烟和年龄较大与较高水平的空气污染影响有关。
Diabetics may be more vulnerable to the harmful effects of ambient air pollutants than healthy individuals. But, the risk factors that lead to susceptibility to air pollution in diabetics have not yet been identified. We examined the effect of exposure to ambient PM10 on chronic symptoms and the pulmonary function tests (PFT) in diabetic and non-diabetic subjects. Also, to investigate possible determinants of susceptibility, we recruited 400 type 2 diabetic and 465 healthy subjects who were investigated for chronic respiratory symptoms (CRSs) and then underwent measurement of forced vital capacity (FVC) and forced expiratory volume 1 (FEV1) according to standard protocol. Percent predicted FEV1 and FVC (FEV1% and FVC%, respectively) for each subject were calculated. Particulate matter (PM10) concentrations at residence place of subjects were estimated using AERMOD dispersion model. The association between PM10 and CRSs was explored using logistic regression. We also used linear regression models controlling for potential confounders to study the association between chronic exposure to PM10 and FEV1% and FVC%. Prevalence of current wheezing, allergy symptom, chest tightness, FEV1/FVC <70%, and physician-diagnosed asthma and COPD was significantly higher among diabetic subjects than non-diabetics. There was no significant difference between percent predicted value of PFT among diabetic and non-diabetic subjects (P < 0.05). We estimated that 1 SD increase in PM10 concentration was associated with a greater risk of having dyspnea by 1.50-fold (95% CI, 1.12–2.01). Higher exposure to PM10 concentration was also significantly associated with lower FVC%. The size of effect for 1 SD μg/m3 (=98.38) increase in PM10 concentration was 3.71% (95% CI, 0.48–4.99) decrease in FVC%. In addition, we indicated that strength of these associations was higher in overweight, smoker, and aged persons. We demonstrated a possible contribution of air pollution to reduced lung function independent of diabetes status. This study suggests that decline in exposure may significantly reduce disease manifestation as dyspnea and impaired lung function. We conduct that higher BMI, smoking, and older age were associated with higher levels of air pollution effects.
影响因子：
7.7
作者：
Gotschi, Thomas;Sunyer, Jordi;Kuenzli, Nino
通讯作者：
Kuenzli, Nino
影响因子：
9.6
作者：
Alexeeff, Stacey E.;Litonjua, Augusto A.;Schwartz, Joel
通讯作者：
Schwartz, Joel