Neurotransmitter release: the last millisecond in the life of a synaptic vesicle.
Neurotransmitter release: the last millisecond in the life of a synaptic vesicle.
复制标题
DOI：
10.1016/j.neuron.2013.10.022
复制
发表时间：
2013-10-30
期刊：
影响因子：
16.2
通讯作者：
Südhof TC
中科院分区：
文献类型：
--
作者：
Südhof TC
During an action potential, Ca2+ entering a presynaptic terminal triggers synaptic vesicle exocytosis and neurotransmitter release in less than a millisecond. How does Ca2+ stimulate release so rapidly and precisely? Work over the last decades revealed that Ca2+-binding to synaptotagmin triggers release by stimulating synaptotagmin-binding to a core machinery composed of SNARE and SM proteins that mediates membrane fusion during exocytosis. Complexin adaptor proteins assist synaptotagmin by activating and clamping this core fusion machinery. Synaptic vesicles containing synaptotagmin are positioned at the active zone, the site of vesicle fusion, by a protein complex containing RIM proteins. RIM proteins simultaneously activate docking and priming of synaptic vesicles and recruit Ca2+-channels to active zones, thereby connecting in a single complex primed synaptic vesicles to Ca2+-channels. This architecture allows direct flow of Ca2+-ions from Ca2+-channels to synaptotagmin, which then triggers fusion, thus mediating tight millisecond coupling of an action potential to neurotransmitter release.
登录
查看更多内容
影响因子：
64.5
作者：
Cao P;Maximov A;Südhof TC
通讯作者：
Südhof TC
影响因子：
56.9
作者：
BROSE, N;PETRENKO, AG;JAHN, R
通讯作者：
JAHN, R
影响因子：
5.5
作者：
DODGE, FA;RAHAMIMO.R
通讯作者：
RAHAMIMO.R
影响因子：
11.4
作者：
Dulubova, I;Sugita, S;Rizo, J
通讯作者：
Rizo, J
DOI：
10.1073/pnas.0611318104
发表时间：
2007-02-20
影响因子：
11.1
作者：
Dulubova, Irina;Khvotchev, Mikhail;Rizo, Josep
通讯作者：
Rizo, Josep