Molecular link between vitamin D and cancer prevention.
Molecular link between vitamin D and cancer prevention.
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DOI：
10.3390/nu5103993
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发表时间：
2013-09-30
期刊：
影响因子：
5.9
通讯作者：
Grant WB
中科院分区：
文献类型：
--
作者：
Moukayed M;Grant WB
维生素D的代谢产物1α，25-二羟基维生素D3（也称为骨化三醇）是一种生物活性分子，从受孕到成年，维持人体内几种靶组织的生理功能。其分子作用模式从立即的非基因组反应到发挥持久基因组效应的长期机制不等。维生素D作用的基因组机制依赖于1α，25-二羟基维生素D3信号通路与共同调节细胞增殖、分化和细胞存活的其他生长因子或激素之间的串扰。体外和体内研究表明维生素D（骨化三醇）在调节细胞生长和发育中的作用。维生素D（骨化三醇）在许多组织中作为抗增殖剂，并显着减缓恶性细胞生长。此外，流行病学研究表明，紫外线-B照射有助于降低癌症风险和患病率，表明维生素D作为一种可行的预防癌症发病率和复发的药物具有潜在作用。随着这种生物活性剂的预防潜力，我们建议癌症正在上升的国家，但在阳光下，因此，维生素D可以很容易地获得，通过提高认识，教育和实施战略，增加补充维生素D在所有年龄组作为预防措施，以减少癌症的风险和患病率。
The metabolite of vitamin D, 1α,25-dihydroxyvitamin D3 (also known as calcitriol), is a biologically active molecule required to maintain the physiological functions of several target tissues in the human body from conception to adulthood. Its molecular mode of action ranges from immediate nongenomic responses to longer term mechanisms that exert persistent genomic effects. The genomic mechanisms of vitamin D action rely on cross talk between 1α,25-dihydroxyvitamin D3 signaling pathways and that of other growth factors or hormones that collectively regulate cell proliferation, differentiation and cell survival. In vitro and in vivo studies demonstrate a role for vitamin D (calcitriol) in modulating cellular growth and development. Vitamin D (calcitriol) acts as an antiproliferative agent in many tissues and significantly slows malignant cellular growth. Moreover, epidemiological studies have suggested that ultraviolet-B exposure can help reduce cancer risk and prevalence, indicating a potential role for vitamin D as a feasible agent to prevent cancer incidence and recurrence. With the preventive potential of this biologically active agent, we suggest that countries where cancer is on the rise—yet where sunlight and, hence, vitamin D may be easily acquired—adopt awareness, education and implementation strategies to increase supplementation with vitamin D in all age groups as a preventive measure to reduce cancer risk and prevalence.
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影响因子：
--
作者：
Akutsu, N;Lin, R;White, JH
通讯作者：
White, JH
影响因子：
3.7
作者：
Beildeck ME;Islam M;Shah S;Welsh J;Byers SW
通讯作者：
Byers SW
DOI：
10.1039/c2pp25251a
发表时间：
2012-12
期刊：
Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology
影响因子：
--
作者：
Bikle DD
通讯作者：
Bikle DD
影响因子：
8
作者：
Bao, BY;Hu, YC;Lee, YF
通讯作者：
Lee, YF
DOI：
10.1073/pnas.85.10.3294
发表时间：
1988-05-01
影响因子：
11.1
作者：
BAKER, AR;MCDONNELL, DP;OMALLEY, BW
通讯作者：
OMALLEY, BW