High frequency functional brain networks in neonates revealed by rapid acquisition resting state fMRI
High frequency functional brain networks in neonates revealed by rapid acquisition resting state fMRI
复制标题
快速采集静息态功能磁共振成像揭示新生儿高频功能脑网络
DOI：
10.1002/hbm.22786
复制
发表时间：
2015
影响因子：
4.8
通讯作者：
Kauppinen RA
中科院分区：
文献类型：
--
作者：
Smith-Collins AP;Luyt K;Heep A;Kauppinen RA
了解空间上遥远的大脑区域如何相互作用以形成功能性大脑网络，以及这些网络在新生儿时期如何发展，为正常大脑发育提供了基本见解，以及大脑障碍和恢复机制如何在未成熟的大脑中发挥作用。表征脑功能网络的一个关键成像工具是检查静息状态下的T2* 加权fMRI信号（静息状态fMRI，rs-fMRI）。大多数rs-fMRI研究都集中在<0.1 Hz时发生的缓慢信号波动上，即使神经元节律和血液动力学反应对这些波动更快，并且有新的证据表明功能性大脑连接的关键信息发生得比这些限制更快。较高频率分量的表征受到标准T2* 回波平面成像（EPI）序列可实现的采样频率的限制。我们描述了使用加速T2* 加权EPI MRI得出的新生儿功能性脑网络连接模式。我们以亚秒级采样频率采集了足月相当年龄早产儿的全脑rs-fMRI数据，并将其与标准EPI采集协议采集的rs-fMRI数据进行了比较。我们提供的第一个证据表明，新生儿快速rs fMRI采集，并采用扩展的频率范围进行分析，允许识别大部分信号功率高于0.2 Hz。因此，我们描述了与成熟度增加相关的大脑连接的变化，这些变化在使用标准的rs-fMRI协议时并不明显。开发优化的新生儿fMRI方案，包括使用高速采集序列，对于理解发育中大脑的生理学和病理生理学至关重要。©2015 Wiley Periodicals，Inc.
Understanding how spatially remote brain regions interact to form functional brain networks, and how these develop during the neonatal period, provides fundamental insights into normal brain development, and how mechanisms of brain disorder and recovery may function in the immature brain. A key imaging tool in characterising functional brain networks is examination of T2*‐weighted fMRI signal during rest (resting state fMRI, rs‐fMRI). The majority of rs‐fMRI studies have concentrated on slow signal fluctuations occurring at <0.1 Hz, even though neuronal rhythms, and haemodynamic responses to these fluctuate more rapidly, and there is emerging evidence for crucial information about functional brain connectivity occurring more rapidly than these limits. The characterisation of higher frequency components has been limited by the sampling frequency achievable with standard T2* echoplanar imaging (EPI) sequences. We describe patterns of neonatal functional brain network connectivity derived using accelerated T2*‐weighted EPI MRI. We acquired whole brain rs‐fMRI data, at subsecond sampling frequency, from preterm infants at term equivalent age and compared this to rs‐fMRI data acquired with standard EPI acquisition protocol. We provide the first evidence that rapid rs‐fMRI acquisition in neonates, and adoption of an extended frequency range for analysis, allows identification of a substantial proportion of signal power residing above 0.2 Hz. We thereby describe changes in brain connectivity associated with increasing maturity which are not evident using standard rs‐fMRI protocols. Development of optimised neonatal fMRI protocols, including use of high speed acquisition sequences, is crucial for understanding the physiology and pathophysiology of the developing brain.Hum Brain Mapp 36:2483–2494, 2015. ©2015 Wiley Periodicals, Inc.
影响因子：
4.2
作者：
White, Thomas P.;Symington, Iona;Castellanos, Nazareth P.;Brittain, Philip J.;Walsh, Sean Froudist;Nam, Kie-Woo;Sato, Joao R.;Allin, Matthew P. G.;Shergill, Sukhi S.;Murray, Robin M.;Williams, Steve C. R.;Nosarti, Chiara
通讯作者：
Nosarti, Chiara
影响因子：
3.7
作者：
Smyser, Christopher D.;Inder, Terrie E.;Neil, Jeffrey J.
通讯作者：
Neil, Jeffrey J.
7T 人类脑干 fMRI 心脏伪影校正
影响因子：
5.7
作者：
L. Kasper;S. Martí;S. Vannesjö;C. Hutton;R. Dolan;N. Weiskopf;K. Prüssmann;K. Stephan
通讯作者：
K. Stephan