Ionization quenching correction for a 3D scintillator detector exposed to scanning proton beams.
Ionization quenching correction for a 3D scintillator detector exposed to scanning proton beams.
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DOI：
10.1088/1361-6560/ab7876
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发表时间：
2020-04-06
影响因子：
3.5
通讯作者：
Beddar S
中科院分区：
文献类型：
--
作者：
Alsanea F;Darne C;Robertson D;Beddar S
在粒子治疗中，为了获得准确的剂量测量，必须对电离室中的电离猝灭现象进行校正。本研究的目的是开发一种方法，用于校正暴露于质子笔形束的3D闪烁体探测器的相机投影测量。Birks的电离猝灭模型和二次电子能量沉积（EDSE）模型被用来校正由原型3D闪烁体探测器捕获的光。探测器由一个20 cm × 20 cm × 20 cm的液体闪烁体和三个摄像机组成。探测器在德克萨斯大学MD安德森癌症中心的质子治疗中心暴露于四种质子束能量（84.6、100.9、144.9和161.6 MeV）。使用经验证的蒙特卡罗（MC）模拟获得剂量和轨迹平均线性能量转移（LET）。将校正的光输出与MC模拟计算的剂量进行比较。光学伪影校正用于校正空气-闪烁体界面处的折射和图像透视。这些校正没有考虑到图像中心轴以外数据的非正交积分。因此，我们比较了光输出的积分MC剂量和LET沿着的非正交路径后占的数据的非正交积分，校正后的光输出降低了剂量误差在布拉格峰区从15%到3%的低质子束能量。总体而言，使用Birks模型和EDSE模型的布拉格峰区域的剂量分别小于MC剂量的±3%和±7%。我们已经改进了Birks的模型淬火校正在3D照射器中的应用，通过将剂量和LET 3D网格数值投影到相机投影。这项研究表明，闪烁体投影可以使用中心轴处的平均LET值进行校正。
The ionization quenching phenomenon in scintillators must be corrected to obtain accurate dosimetry in particle therapy. The purpose of this study was to develop a methodology for correcting camera projection measurements of a 3D scintillator detector exposed to proton pencil beams. Birks’ ionization quenching model and the energy deposition by secondary electrons (EDSE) model were used to correct the light captured by a prototype 3D scintillator detector. The detector was made of a 20 cm × 20 cm × 20 cm tank filled with liquid scintillator, and three cameras. The detector was exposed to four proton-beam energies (84.6, 100.9, 144.9, and 161.6 MeV) at The University of Texas MD Anderson Cancer Center’s Proton Therapy Center. The dose and track averaged linear energy transfer (LET) were obtained using validated Monte Carlo (MC) simulations. The corrected light output was compared to the dose calculated by the MC simulation. Optical artefact corrections were used to correct for refraction at the air-scintillator interface, and image perspective. These corrections did not account for the non-orthogonal integration of data off the central axis of the image. Therefore, we compared the light output to an integrated MC dose and LET along the non-orthogonal path. After accounting for the non-orthogonal integration of the data, the corrected light output reduced the dose error at the Bragg peak region from 15% to 3% for low proton-beam energies. Overall, the doses at the Bragg peak region using the Birks’ model and EDSE model were less than ±3% and ±7% of the MC dose, respectively. We have improved the application of Birks’ model quenching corrections in 3D scintillators by numerically projecting the dose and LET 3D grid to camera projections. This study shows that scintillator projections can be corrected using average LET values at the central axes.
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DOI：
10.1016/j.nima.2019.05.038
发表时间：
2019-09-21
影响因子：
1.4
作者：
Alsanea, Fahed;Darne, Chinmay;Beddar, Sam
通讯作者：
Beddar, Sam
影响因子：
3.8
作者：
Archambault, L.;Poenisch, F.;Beddar, S.
通讯作者：
Beddar, S.
影响因子：
2.1
作者：
Almurayshid, Mansour;Helo, Yusuf;Gibson, Adam
通讯作者：
Gibson, Adam
影响因子：
3.8
作者：
Beddar, Sam;Archambault, Louis;Mohan, Radhe
通讯作者：
Mohan, Radhe
影响因子：
3.8
作者：
Sawakuchi, Gabriel O.;Mirkovic, Dragan;Titt, Uwe
通讯作者：
Titt, Uwe