On the cutting edge: post-translational modifications in cytokinesis.

On the cutting edge: post-translational modifications in cytokinesis.
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最前沿:胞质分裂的翻译后修饰。

DOI:
10.1016/j.tcb.2011.01.006
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发表时间:
2011-05
影响因子:
19
通讯作者:
Gould KL
Gould KL
中科院分区:
生物学1区
文献类型:
--
作者:
Bohnert KA;Gould KL

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胞质分裂代表细胞周期的最后阶段,其中两个子细胞,每个子细胞具有其复制基因组的互补物,物理分离。在这个过程的核心是高度保守的机制,负责指定分裂平面,建立一个收缩装置,并最终将细胞一分为二。虽然贡献蛋白质的“部件列表”已经被很好地描述,这些部件在空间和时间上被调节的机制才刚刚开始被理解。随着生物化学和蛋白质组学分析的发展,最近的研究发现了翻译后修饰在胞质分裂调控中的多种新作用。在这里,我们回顾这些最新的发现,并解释我们目前的理解胞质分裂的相关修改。
Cytokinesis represents the final stage in the cell cycle, in which two daughter cells, each with their complement of the duplicated genome, physically separate. At the core of this process sits highly conserved machinery responsible for specifying the plane of division, building a contractile apparatus and ultimately cleaving cells in two. Although the ‘parts list’ of contributing proteins has been well described, mechanisms by which these parts are spatially and temporally regulated are only beginning to be understood. With advancements in biochemical and proteomic analyses, recent work has uncovered multiple new roles for post-translational modifications in the regulation of cytokinesis. Here, we review these latest findings and interpret our current understanding of cytokinesis in light of relevant modifications.
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影响因子: --
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