COVID-19 Vaccine Does Not Increase the Risk of Disease Flare-Ups among Patients with Autoimmune and Immune-Mediated Diseases.
COVID-19 Vaccine Does Not Increase the Risk of Disease Flare-Ups among Patients with Autoimmune and Immune-Mediated Diseases.
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DOI：
10.3390/jpm11121283
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发表时间：
2021-12-02
影响因子：
--
通讯作者：
Baicus C
中科院分区：
文献类型：
--
作者：
Pinte L;Negoi F;Ionescu GD;Caraiola S;Balaban DV;Badea C;Mazilu D;Dumitrescu B;Mateescu B;Ionescu R;Parvu MI;Baicus C
背景：描述先前健康个体中疫苗接种后自身免疫现象的报告增加了对免疫疾病患者疾病爆发风险的担忧。我们的目的是在 6 个月的随访期内评估接种 COVID-19（2019 冠状病毒病）疫苗后疾病爆发的潜在风险。方法：我们进行了一项前瞻性队列研究，招募了患有自身免疫和免疫介导疾病的患者，他们在网上和医院评估期间自愿完成了我们的调查问卷。根据他们接受疫苗的决定，患者被分为两组（已接种疫苗的组和未接种疫苗的组）。选择不接种疫苗的参与者作为突发事件的对照组。结果：医院评估期间 (222/623) 和在线注册 (401/623) 后，共有 623 名患者纳入研究，其中 416 名接种疫苗的患者和 207 名未接种疫苗的患者。接种疫苗和未接种疫苗的患者之间的发病风险没有差异（1.16 次发病/100 名患者月，1.72 次发病/100 名患者月，p = 0.245）。这些疾病的发作与患有一种以上的免疫疾病有关，并且与过去一年中的一次疾病发作有关。结论：在中位随访 5.9 个月后，我们没有发现患有自身免疫/免疫介导疾病的患者在接种 COVID-19 疫苗后发病风险增加。根据我们的结果，此类患者不应有明显的疫苗犹豫原因。
Background: Reports describing post-vaccine autoimmune phenomena, in previously healthy individuals, increased the concerns regarding the risk of disease flare-ups in patients with immune diseases. We aimed to assess the potential risk of disease flare-up, after receiving the COVID-19 (Coronavirus disease 2019) vaccine, during a follow-up period of 6 months. Methods: We performed a prospective cohort study, enrolling the patients with autoimmune- and immune-mediated diseases who voluntarily completed our questionnaire, both online and during hospital evaluations. Based on their decision to receive the vaccine, the patients were divided into two groups (vaccinated and non-vaccinated). Participants who chose not to receive the vaccine served as a control group in terms of flare-ups. Results: A total of 623 patients, 416 vaccinated and 207 non-vaccinated, were included in the study during hospital evaluations (222/623) and after online (401/623) enrolment. There was no difference concerning the risk of flare-up between vaccinated and non-vaccinated patients (1.16, versus 1.72 flare-ups/100 patients-months, p = 0.245). The flare-ups were associated with having more than one immune disease, and with a previous flare-up during the past year. Conclusions: We did not find an increased risk of flare-up following COVID-19 vaccination in patients with autoimmune-/immune-mediated diseases, after a median follow-up of 5.9 months. According to our results, there should not be an obvious reason for vaccine hesitancy among this category of patients.
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香港类风湿关节炎患者中的两剂共证于19号疫苗接种和可能的关节炎炎症。
影响因子：
27.4
作者：
Li X;Tong X;Yeung WWY;Kuan P;Yum SHH;Chui CSL;Lai FTT;Wan EYF;Wong CKH;Chan EWY;Lau CS;Wong ICK
通讯作者：
Wong ICK
影响因子：
4
作者：
Cherian S;Paul A;Ahmed S;Alias B;Manoj M;Santhosh AK;Varghese DR;Krishnan N;Shenoy P
通讯作者：
Shenoy P
DOI：
10.1016/s2665-9913(21)00108-9
发表时间：
2021-07
期刊：
The Lancet. Rheumatology
影响因子：
--
作者：
Terracina KA;Tan FK
通讯作者：
Tan FK
影响因子：
1.9
作者：
Baicus, Cristian;Delcea, Caterina;Dan, Gheorghe Andrei
通讯作者：
Dan, Gheorghe Andrei
影响因子：
9.9
作者：
Burns, Ted M.;Conaway, Mark;Sanders, Donald B.
通讯作者：
Sanders, Donald B.