The Social Responsiveness Scale (SRS-2) in school-age children with Down syndrome at low risk for autism spectrum disorder.
The Social Responsiveness Scale (SRS-2) in school-age children with Down syndrome at low risk for autism spectrum disorder.
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DOI：
10.1177/2396941520962406
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发表时间：
2020-01
影响因子：
--
通讯作者：
Channell MM
中科院分区：
文献类型：
--
作者：
Channell MM
很少有人知道自闭症谱系障碍（ASD）的症状是如何出现在唐氏综合征（DS）患者身上的。一些行为可能是ASD共病的症状，或更广泛地代表DS表型。先前的一项研究记录了没有合并ASD的DS青少年和年轻人的ASD样症状升高，使用常见的ASD风险筛查工具-社会反应量表（SRS）。当前的研究使用SRS-2对患有DS的年幼儿童应用了类似的方法。主要目的是记录合并ASD风险低的DS儿童的ASD样症状模式，以区分一般DS中可能存在的症状。SRS-2标准评分分析了40名6-11岁DS儿童的样本，这些儿童根据社会沟通问卷（SCQ）筛选器被认为是ASD的低风险。其他发育特征（即，年龄、非语言智商、表达性语言）、社交技能和问题行为也在整个样本中进行了检查。与正常人群样本相比，该样本的SRS-2评分显著升高。在SRS-2亚领域中观察到ASD样神经病学模式。这些发现与先前研究的结果相似。然而，在两个样本中观察到细微的差异，这可能代表了该人群中不同年龄段的发育差异。复制和扩展先前的研究结果，某些ASD样行为可能发生在患有DS的个体中，这些个体患有共病ASD的风险较低。含义：了解ASD样行为的模式，发生在DS儿童谁是在低风险的共病ASD将有助于临床医生在筛选和识别工作。特别是，它将导致更好地规范行为或症状，这些行为或症状不是DS表型的特征，因此是该人群中共病ASD的红旗。
Little is known about how autism spectrum disorder (ASD) symptoms present in individuals with Down syndrome (DS). Some behaviors may be symptomatic of comorbid ASD or more broadly representative of the DS phenotype. A prior research study documented elevated ASD-like symptoms in adolescents and young adults with DS without comorbid ASD, using a common ASD risk screening tool—the Social Responsiveness Scale (SRS). The current study applied a similar approach to younger children with DS using the SRS-2. The primary aim was to document patterns of ASD-like symptoms in children with DS at low risk of comorbid ASD to distinguish the symptoms that may be present across DS in general. SRS-2 standard scores were analyzed in a sample of 40 children with DS, 6–11 years old, who were considered to be at low risk for ASD based on the Social Communication Questionnaire (SCQ) screener. Other developmental characteristics (i.e., age, nonverbal IQ, expressive language), social skills, and problem behaviors were also examined across the sample. SRS-2 scores were significantly elevated in this sample compared to the normative population sample. A pattern of ASD-like symptomatology was observed across SRS-2 subdomains. These findings were similar to the findings of the prior study. However, nuanced differences were observed across the two samples that may represent developmental differences across different ages in this population. Replicating and extending a prior study's findings, certain ASD-like behaviors may occur in individuals with DS who are at low risk for comorbid ASD. Implications: Understanding the pattern of ASD-like behaviors that occur in children with DS who are at low risk for comorbid ASD will help clinicians in screening and identification efforts. In particular, it will lead to better specification of the behaviors or symptoms that are not characteristic of the DS phenotype and thus are red flags for comorbid ASD in this population.
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DOI：
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发表时间：
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影响因子：
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作者：
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影响因子：
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