Dialysis-requiring acute renal failure increases the risk of progressive chronic kidney disease.

Dialysis-requiring acute renal failure increases the risk of progressive chronic kidney disease.
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DOI:
10.1038/ki.2009.289
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发表时间:
2009-10
影响因子:
19.6
通讯作者:
Hsu, Chi-yuan
Hsu, Chi-yuan
中科院分区:
医学1区
文献类型:
--
作者:
Lo, Lowell J.;Go, Alan S.;Chertow, Glenn M.;McCulloch, Charles E.;Fan, Dongjie;Ordonez, Juan D.;Hsu, Chi-yuan

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To determine whether acute renal failure (ARF) increases the long-term risk of progressive chronic kidney disease (CKD), we studied the outcome of patients whose initial kidney function was normal or near normal but who had an episode of dialysis-requiring ARF and did not develop end-stage renal disease within 30 days following hospital discharge. The study encompassed 556,090 adult members of Kaiser Permanente of Northern California hospitalized over an 8 year period, who had pre-admission estimated glomerular filtration rates (eGFR) equivalent to or greater than 45 ml/min/1.73 m2 and who survived hospitalization. After controlling for potential confounders such as baseline level of eGFR and diabetes status, dialysis-requiring ARF was independently associated with a 28-fold increase in the risk of developing stage 4 or 5 CKD and more than a twofold increased risk of death. Our study shows that in a large, community-based cohort of patients with pre-existing normal or near normal kidney function, an episode of dialysis-requiring ARF was a strong independent risk factor for a long-term risk of progressive CKD and mortality.
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