An immunophilin is a component of the insect ecdysone receptor (EcR) complex.
An immunophilin is a component of the insect ecdysone receptor (EcR) complex.
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亲免素是昆虫蜕皮激素受体 (EcR) 复合物的组成部分。
DOI:
10.1016/s0965-1748(97)00080-5
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发表时间:
1997
影响因子:
3.8
通讯作者:
Gilbert,LI
中科院分区:
文献类型:
--
作者:
Song,Q;Alnemri,ES;Litwack,G;Gilbert,LI
The ecdysone receptor (EcR) complex has been identified in the prothoracic gland of Manduca sexta by specific immunoprecipitation and Western blot analyses, and includes EcR, ultraspiracle (USP) and FKBP46. The EcR complex binds ponasterone A in a dose-dependent manner with a Kdof 7.04×10−9M. Immunocytochemistry revealed that EcR, USP and FKBP46 were localized within the nucleus of the prothoracic gland cells, and suggested that the developmental expression patterns of EcR and USP changed in concert with the hemolymph ecdysteroid titer whereas that of FKBP46 did not. The composite results suggest that the hemolymph ecdysteroid titer, of which 20 hydroxyecdysone is the major component, modulates the expression of both EcR and USP in the prothoracic gland to achieve feedback regulation.
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DOI:
--
发表时间:
1996
期刊:
影响因子:
--
作者:
P. Cherbas;L. Cherbas
通讯作者:
L. Cherbas
DOI:
10.1210/mend.9.11.8584032
发表时间:
1995
期刊:
Molecular endocrinology (Baltimore, Md.)
影响因子:
--
作者:
Czar,MJ;Lyons,RH;Welsh,MJ;Renoir,JM;Pratt,WB
通讯作者:
Pratt,WB
影响因子:
3.8
作者:
CHO, WL;KAPITSKAYA, MZ;RAIKHEL, AS
通讯作者:
RAIKHEL, AS
影响因子:
20.3
作者:
W. Pratt;D. Toft
通讯作者:
W. Pratt;D. Toft
影响因子:
11.4
作者:
KARIM, FD;THUMMEL, CS
通讯作者:
THUMMEL, CS