(18)F-FDG Uptake on PET/CT in Symptomatic versus Asymptomatic Carotid Disease: a Meta-Analysis.
(18)F-FDG Uptake on PET/CT in Symptomatic versus Asymptomatic Carotid Disease: a Meta-Analysis.
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DOI：
10.1016/j.ejvs.2018.03.028
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发表时间：
2018-08
期刊：
影响因子：
--
通讯作者：
Coughlin PA
中科院分区：
文献类型：
--
作者：
Chowdhury MM;Tarkin JM;Evans NR;Le E;Warburton EA;Hayes PD;Rudd JHF;Coughlin PA
正电子发射断层扫描（PET）/计算机断层扫描（CT）在确定动脉疾病炎症中的作用尚未明确。这可以提供关于动脉粥样硬化疾病中动脉壁炎症的信息，并可以深入了解斑块稳定性。本综述的目的是对PET/CT与18F-FDG（氟脱氧葡萄糖）摄取在有症状和无症状颈动脉疾病中的应用进行荟萃分析。这是一项系统性综述，遵循PRISMA指南，询问了2001年1月至2017年5月的MEDLINE数据库。检索结合了术语“炎症”、“FDG”和“卒中”。检索标准包括所有类型的研究，主要结果是通过18F-FDG摄取确定的动脉血管炎症程度。分析涉及使用随机效应模型对合并数据进行逆加权方差估计。荟萃分析共纳入14篇文章（539例患者）。比较有症状与无症状疾病的颈动脉18F-FDG摄取，标准平均差异为0.94（95%CI 0.58-1.130; p <0.0001; I2 = 65%）。使用18F-FDG的PET/CT可以显示颈动脉斑块炎症，并且是症状性疾病的标志物。需要进一步的研究来了解PET/CT作为风险预测工具的临床意义。
The role of positron emission tomography (PET)/computed tomography (CT) in the determination of inflammation in arterial disease is not well defined. This can provide information about arterial wall inflammation in atherosclerotic disease, and may give insight into plaque stability. The aim of this review was to perform a meta-analysis of PET/CT with 18F-FDG (fluorodeoxyglucose) uptake in symptomatic and asymptomatic carotid artery disease. This was a systematic review, following PRISMA guidelines, which interrogated the MEDLINE database from January 2001 to May 2017. The search combined the terms, “inflammation”, “FDG”, and “stroke”. The search criteria included all types of studies, with a primary outcome of the degree of arterial vascular inflammation determined by 18F-FDG uptake. Analysis involved an inverse weighted variance estimate of pooled data, using a random effects model. A total of 14 articles (539 patients) were included in the meta-analysis. Comparing carotid artery 18F-FDG uptake in symptomatic versus asymptomatic disease yielded a standard mean difference of 0.94 (95% CI 0.58–1.130; p < .0001; I2 = 65%). PET/CT using 18F-FDG can demonstrate carotid plaque inflammation, and is a marker of symptomatic disease. Further studies are required to understand the clinical implication of PET/CT as a risk prediction tool.
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