Effect of pneumococcal conjugate vaccine availability on Streptococcus pneumoniae infections and genetic recombination in Zhejiang, China from 2009 to 2019.
Effect of pneumococcal conjugate vaccine availability on Streptococcus pneumoniae infections and genetic recombination in Zhejiang, China from 2009 to 2019.
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DOI：
10.1080/22221751.2022.2040921
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发表时间：
2022-12
影响因子：
13.2
通讯作者：
Yu Y
中科院分区：
文献类型：
--
作者：
Wu X;Zhao S;Jiang Y;Xiang X;Ge L;Chen Q;Wang Y;Vidal JE;Yu Y
肺炎球菌性肺炎是全球儿童死亡的主要原因之一。肺炎球菌结合疫苗（PCV）被认为是预防肺炎球菌病（PD）的最有效策略，但PCV疫苗接种的暂停如何影响PD的患病率或肺炎链球菌的遗传进化尚不清楚。基于中国独特的PCV引入时间轴（2015年4月至2017年4月期间疫苗不可用），我们旨在评价PCV供应中断对PD和肺炎球菌基因组变异的影响。从2009年至2019年，从中国浙江省的8个地点回顾性收集了肺炎球菌分离株（n = 386），其中鉴定了184株致病性（来自无菌和感染部位的分离株）菌株。进行中断时间序列分析以估计PD的变化，并通过SNP调用估计全基因组测序菌株的重组频率。我们发现，PD和肺炎球菌基因组变异受到PCV可用性中断的影响。在所有LRTI病例中，疫苗型肺炎球菌LRTI（VT-LRTI）的比例（70%）在PCV 7后期下降至30%，一旦PCV 7在2015年4月不可用，儿童中的比例反弹至70%（p = 0.0007）。去除PCV后，主要克隆CC 271菌株显示重组频率降低（p = 0.0293）（从2.82 ± 1.16降低至0.72 ± 0.21）。我们的研究首次说明，VT-LRTI在中国疫苗供应中断时波动，并导致疫苗类型重组频率下降。在全国范围内推广持续的疫苗接种计划，加强S。pneumoniae的分子流行病学监测对PD预防至关重要。
Pneumococcal pneumonia is one of the main reasons for child death worldwide. Pneumococcal conjugate vaccines (PCVs) are considered the most effective strategy for pneumococcal disease (PD) prevention, but how a pause in PCV vaccination affects the prevalence of PD or the genetic evolution of Streptococcus pneumoniae genetic evolution is unknown. Based on the unique PCV introduction timeline (vaccine unavailable during April 2015-April 2017) in China, we aimed to evaluate the effect of interrupted PCV availability on PD and pneumococcal genome variation. Pneumococcal isolates (n = 386) were collected retrospectively from eight sites in Zhejiang, China from 2009 to 2019 in which 184 pathogenic (isolates from sterile and infection sites) strains were identified. An interrupted time series analysis was conducted to estimate changes in PD and the recombination frequency of whole genome-sequenced strains was estimated via SNP calling. We found that both PD and pneumococcal genome variation were affected by interrupted PCV availability. The proportion (∼70%) of vaccine-type pneumococcal LRTI (VT-LRTI) in all LRTI cases decreased to ∼30% in the later PCV7 period and rebounded to ∼70% in children once PCV7 became unavailable in April 2015 (p = 0.0007). The major clone CC271 strains showed slowed (p = 0.0293) recombination frequency (decreased from 2.82 ± 1.16–0.72 ± 0.21) upon PCV removal. Our study illustrated for the first time that VT-LRTI fluctuated upon interrupted vaccine availability in China and causing a decreased of recombination frequency of vaccine types. Promoting a nationwide continuous vaccination programme and strengthening S. pneumoniae molecular epidemiology surveillance are essential for PD prevention.
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影响因子：
5.8
作者：
Nguyen TK;Tran TH;Roberts CL;Graham SM;Marais BJ
通讯作者：
Marais BJ
影响因子：
2.7
作者：
Kapatai G;Sheppard CL;Al-Shahib A;Litt DJ;Underwood AP;Harrison TG;Fry NK
通讯作者：
Fry NK
影响因子：
4.2
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通讯作者：
Varon E
影响因子：
3.9
作者：
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通讯作者：
Bentley, Stephen D.
影响因子：
6.4
作者：
Lattar, Santiago M.;Wu, Xueqing;Vidal, Jorge E.
通讯作者：
Vidal, Jorge E.