Neurocognitive Functioning in Early School-Age Children with Intestinal Failure.
Neurocognitive Functioning in Early School-Age Children with Intestinal Failure.
复制标题
学龄早期肠衰竭儿童的神经认知功能。
DOI：
10.1097/mpg.0000000000002500
复制
发表时间：
2020
影响因子：
2.9
通讯作者：
P. Wales
中科院分区：
文献类型：
--
作者：
A. Gold;Ashley N. Danguecan;Christina Belza;Stephanie So;N. De Silva;Y. Avitzur;P. Wales
目标
OBJECTIVES
Little is known about school-age functioning in children with intestinal failure (IF). This study examines neurocognitive outcomes of children with IF at ages 4 to 8 years treated at a single centre, along with relevant medical and demographic variables.
METHODS
Between 2012 and 2016, neurocognitive assessments were administered to 28 children receiving treatment in our IF rehabilitation program, and included measures of intelligence, academics, learning/memory, language, visual-motor integration, and fine-motor dexterity. DSM-IV/V criteria were used to diagnose Learning Disability, Intellectual Disability, and/or Attention Deficit/Hyperactivity Disorder.
RESULTS
Intellectual functioning ranged from extremely low to superior (Full Scale IQ range 53 to 123, mean = 89). 46% received a cognitive/learning DSM diagnosis. Total number of first-year septic episodes correlated with poorer outcomes on the most cognitive measures. Adjusting for gestational age (61% were born <37 weeks), number of first-year septic episodes negatively predicted working memory, visual-motor integration, and visual memory scores. Additional factors correlating with poorer outcomes on ≥2 cognitive measures included length of first-year admissions, necrotizing enterocolitis diagnosis, and first-year sustained conjugated hyperbilirubinemia. Having ≥2 first-year septic episodes increased the likelihood of poorer outcome. Having a sibling was a significant positive predictor of working memory, processing speed, reading, and verbal learning skills.
CONCLUSIONS
Our data provides preliminary evidence that children with IF are at risk of neurocognitive problems at early school age. Managing septic events during the first year is one strategy that may help reduce long-term neurocognitive risk in this population.
影响因子：
5.1
作者：
Martin, Camilia R.;Dammann, Olaf;Allred, Elizabeth N.;Patel, Sonal;O'Shea, T. Michael;Kuban, Karl C. K.;Leviton, Alan
通讯作者：
Leviton, Alan
DOI：
10.1111/j.1741-3737.2012.01011.x
发表时间：
2012-10-01
期刊：
Journal of marriage and the family
影响因子：
--
作者：
McHale SM;Updegraff KA;Whiteman SD
通讯作者：
Whiteman SD