DNA recognition and superstructure formation by helix-turn-helix proteins.

DNA recognition and superstructure formation by helix-turn-helix proteins.
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螺旋-转角-螺旋蛋白的 DNA 识别和超结构形成。

DOI:
10.1093/protein/8.4.329
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发表时间:
1995
期刊:
Protein engineering
影响因子:
--
通讯作者:
Mark Gerstein
Mark Gerstein
中科院分区:
--
文献类型:
--
作者:
Masashi Suzuki;Naoto Yagi;Mark Gerstein

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螺旋转螺旋蛋白识别DNA的方式是通过比较它们的序列、结构和结合特异性来分析的。这些蛋白质中的单个识别螺旋与四个具有相同几何形状的DNA碱基对结合。然而,蛋白质二聚体中的对识别螺旋可以具有不同的分离和取向。这些差异用于区分具有不同上层结构的dna,特别是四个碱基对之间不同数量的碱基对。
The way helix-turn-helix proteins recognize DNA is analysed by comparing their sequences, structures, and binding specificities. Individual recognition helices in these proteins bind to four DNA base pairs with the same geometry. However, pairs of recognition helices in the protein dimers can have different separations and orientations. These differences are used for discriminating between DNAs which have different superstructures, in particular, different numbers of base pairs between sets of the four base pairs.
蛋白质-核酸相互作用的结构研究。
DOI: 10.1146/annurev.bb.12.060183.001355
发表时间: 1983
期刊: Annual review of biophysics and bioengineering
影响因子: --
作者:
Ohlendorf,DH;Matthews,BW
通讯作者: Matthews,BW