Home-Based Music Therapy to Support Bulbar and Respiratory Functions of Persons with Early and Mid-Stage Amyotrophic Lateral Sclerosis-Protocol and Results from a Feasibility Study.
Home-Based Music Therapy to Support Bulbar and Respiratory Functions of Persons with Early and Mid-Stage Amyotrophic Lateral Sclerosis-Protocol and Results from a Feasibility Study.
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DOI：
10.3390/brainsci12040494
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发表时间：
2022-04-13
期刊：
影响因子：
3.3
通讯作者：
Street, Alexander J.
中科院分区：
文献类型：
--
作者：
Apreleva Kolomeytseva, Alisa T.;Brylev, Lev;Eshghi, Marziye;Bottaeva, Zhanna;Zhang, Jufen;Fachner, Jorg C.;Street, Alexander J.
关键词：
呼吸衰竭、营养不良、吸入性肺炎和脱水是肌萎缩侧索硬化症（ALS）患者死亡的先兆。丧失自然交流能力被认为是ALS最糟糕的方面之一。这项首次测试音乐疗法用于ALS延髓和呼吸康复的可行性的研究采用了混合方法的系列病例研究设计，并进行了重复测量。符合纳入标准的新确诊患者被邀请参与，直至达到所需的样本量（n = 8）。该方案在患者家中每周实施两次，为期六周。同时提供了供独立练习的个性化运动组。收集了可行性数据（招募情况、留存率、依从性、耐受性、自我激励和个人印象），并对延髓和呼吸方面的变化进行了客观测量。
结果：高招募率（100%）、高留存率（87.5%）以及对治疗的高平均依从性（95.4%）为研究方案的可行性提供了证据。治疗的耐受性良好。对建议的独立锻炼常规的平均依从性为53%。确定了用于评估治疗引起的延髓和呼吸功能变化的结果测量指标。研究结果表明，该方案在ALS早期和中期使用是安全的，并且音乐疗法对参与者的延髓和呼吸功能有益。在大多数结果参数中观察到平均趋势表明这些功能在治疗期间得以维持或改善，这些参数包括：最大吸气压力、最大呼气压力、呼气峰流量、神经学研究中心—延髓功能量表的言语和吞咽子量表、最长发声时间、最大交替重复率、最大顺序重复率、抖动、闪烁、噪声与谐波比、语速、言语停顿比、停顿频率、鼻音过重程度、喉前庭关闭时间、最大咽缩窄面积、舌骨峰值位置、总咽部残留C24面积。
结论：所建议的设计和方案经过一些修改（包括鼻音的空气动力学测量、简化的语音采样和心理筛查）后，可用于更大规模的研究。
Respiratory failure, malnutrition, aspiration pneumonia, and dehydration are the precursors to mortality in ALS. Loss of natural communication is considered one of the worst aspects of ALS. This first study to test the feasibility of a music therapy protocol for bulbar and respiratory rehabilitation in ALS employs a mixed-methods case study series design with repeated measures. Newly diagnosed patients meeting the inclusion criteria were invited to participate, until the desired sample size (n = 8) was achieved. The protocol was delivered to participants in their homes twice weekly for six weeks. Individualised exercise sets for independent practice were provided. Feasibility data (recruitment, retention, adherence, tolerability, self-motivation and personal impressions) were collected. Bulbar and respiratory changes were objectively measured. Results. A high recruitment rate (100%), a high retention rate (87.5%) and high mean adherence to treatment (95.4%) provide evidence for the feasibility of the study protocol. The treatment was well tolerated. Mean adherence to the suggested independent exercise routine was 53%. The outcome measurements to evaluate the therapy-induced change in bulbar and respiratory functions were defined. Findings suggest that the protocol is safe to use in early- and mid-stage ALS and that music therapy was beneficial for the participants’ bulbar and respiratory functions. Mean trends suggesting that these functions were sustained or improved during the treatment period were observed for most outcome parameters: Maximal Inspiratory Pressure, Maximal Expiratory Pressure, Peak Expiratory Flow, the Center for Neurologic Study—Bulbar Function Scale speech and swallowing subscales, Maximum Phonation Time, Maximum Repetition Rate—Alternating, Maximum Repetition Rate—Sequential, Jitter, Shimmer, NHR, Speaking rate, Speech–pause ratio, Pause frequency, hypernasality level, Time-to-Laryngeal Vestibule Closure, Maximum Pharyngeal Constriction Area, Peak Position of the Hyoid Bone, Total Pharyngeal Residue C24area. Conclusion. The suggested design and protocol are feasible for a larger study, with some modifications, including aerodynamic measure of nasalance, abbreviated voice sampling and psychological screening.
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DOI：
10.17116/jnevro201811812136
发表时间：
2018-01-01
影响因子：
--
作者：
Chernenkaya, V Yu;Gorbachev, K V;Guekht, A B
通讯作者：
Guekht, A B
影响因子：
5.3
作者：
Bonafede R;Mariotti R
通讯作者：
Mariotti R
DOI：
10.1016/j.pmr.2008.02.003
发表时间：
2008-08-01
影响因子：
1.7
作者：
Chen, Amy;Montes, Jacqueline;Mitsumoto, Hiroshi
通讯作者：
Mitsumoto, Hiroshi
DOI：
10.3109/17482960802566824
发表时间：
2009-10
期刊：
Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases
影响因子：
--
作者：
Chiò A;Logroscino G;Hardiman O;Swingler R;Mitchell D;Beghi E;Traynor BG;Eurals Consortium
通讯作者：
Eurals Consortium
影响因子：
2.9
作者：
Bukowska AA;Krężałek P;Mirek E;Bujas P;Marchewka A
通讯作者：
Marchewka A