Designing natural and synthetic immune tissues.
Designing natural and synthetic immune tissues.
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DOI：
10.1038/s41563-018-0077-6
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发表时间：
2018-06
期刊：
影响因子：
41.2
通讯作者：
Jewell CM
中科院分区：
文献类型：
--
作者：
Gosselin EA;Eppler HB;Bromberg JS;Jewell CM
疫苗和免疫疗法为公共卫生提供了巨大的改善，但在大多数研究的进行地点（细胞培养和动物模型）与最终在人类中的应用之间存在根本性的脱节。工程免疫组织和器官，如骨髓、胸腺、淋巴结和脾脏，可能有助于克服这些障碍。从根本上说，设计的免疫组织可以作为体外工具，更准确地研究人类免疫功能和疾病，而作为下一代疫苗或免疫疗法植入的免疫组织可以直接按需控制免疫功能的产生和调节。在这篇综述中，我们讨论了最近的跨学科战略，合并材料科学和免疫学，创造工程免疫组织在体外和体内。我们还强调了这些方法所面临的障碍，以及与现有临床选择、相关动物模型和其他新兴技术进行比较的必要性。
Vaccines and immunotherapies have provided enormous improvements for public health, but there are fundamental disconnects between where most studies are performed – in cell culture and animal models – and the ultimate application in humans. Engineering immune tissues and organs, such as bone marrow, thymus, lymph nodes, and spleen, could be instrumental in overcoming these hurdles. Fundamentally, designed immune tissues could serve as in vitro tools to more accurately study human immune function and disease, while immune tissues engineered for implantation as next-generation vaccines or immunotherapies could enable direct, on-demand control over generation and regulation of immune function. In this review, we discuss recent interdisciplinary strategies that are merging materials science and immunology to create engineered immune tissues in vitro and in vivo. We also highlight the hurdles facing these approaches and the need for comparison to existing clinical options, relevant animal models, and other emerging technologies.
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影响因子：
56.9
作者：
Butcher, EC;Picker, LJ
通讯作者：
Picker, LJ
DOI：
10.1158/1078-0432.ccr-14-2696
发表时间：
2015-05-01
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
--
作者：
Bruns H;Bessell C;Varela JC;Haupt C;Fang J;Pasemann S;Mackensen A;Oelke M;Schneck JP;Schütz C
通讯作者：
Schütz C
影响因子：
3
作者：
Cook, Matthew M.;Futrega, Kathryn;Doran, Michael
通讯作者：
Doran, Michael
影响因子：
16.6
作者：
Dura, Burak;Dougan, Stephanie K.;Voldman, Joel
通讯作者：
Voldman, Joel
影响因子：
15.9
作者：
Abarrategi, Ander;Foster, Katie;Bonnet, Dominique
通讯作者：
Bonnet, Dominique