Accurate macromolecular structures using minimal measurements from X-ray free-electron lasers.
Accurate macromolecular structures using minimal measurements from X-ray free-electron lasers.
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DOI：
10.1038/nmeth.2887
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发表时间：
2014-05
期刊：
影响因子：
48
通讯作者：
Sauter, Nicholas K.
中科院分区：
文献类型：
--
作者：
Hattne, Johan;Echols, Nathaniel;Rosalie Tran;Kern, Jan;Gildea, Richard J.;Brewster, Aaron S.;Alonso-Mori, Roberto;Gloeckner, Carina;Hellmich, Julia;Laksmono, Hartawan;Sierra, Raymond G.;Lassalle-Kaiser, Benedikt;Lampe, Alyssa;Han, Guangye;Gul, Sheraz;DiFiore, Doerte;Milathianaki, Despina;Fry, Alan R.;Miahnahri, Alan;White, William E.;Schafer, Donald W.;Seibert, M. Marvin;Koglin, Jason E.;Sokaras, Dimosthenis;Weng, Tsu-Chien;Sellberg, Jonas;Latimers, Matthew J.;Glatzel, Pieter;Zwart, Petrus H.;Grosse-Kunstleve, Ralf W.;Bogan, Michael J.;Messerschmidt, Marc;Williams, Garth J.;Boutet, Sebastien;Messinger, Johannes;Zouni, Athina;Yano, Junko;Bergmann, Uwe;Yachandra, Vittal K.;Adams, Paul D.;Sauter, Nicholas K.
X射线自由电子激光(XFEL)光源使人们能够在自然条件下利用结晶学来解析三维大分子结构，并且不会受到辐射损伤。然而，迄今为止的结果一直受到挑战的限制，即从不同种类的微晶体群体中获得准确的布拉格强度，同时对X射线光谱和探测器几何形状进行建模。在这里，我们提出了一种计算方法，旨在从较少的衍射测量中提取统计上有意义的高分辨率信号。
X-ray free-electron laser (XFEL) sources enable the use of crystallography to solve three-dimensional macromolecular structures under native conditions and free from radiation damage. Results to date, however, have been limited by the challenge of deriving accurate Bragg intensities from a heterogeneous population of microcrystals, while at the same time modeling the X-ray spectrum and detector geometry. Here we present a computational approach designed to extract statistically significant high-resolution signals from fewer diffraction measurements.
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DOI：
10.1126/science.1234273
发表时间：
2013-04-26
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Kern J;Alonso-Mori R;Tran R;Hattne J;Gildea RJ;Echols N;Glöckner C;Hellmich J;Laksmono H;Sierra RG;Lassalle-Kaiser B;Koroidov S;Lampe A;Han G;Gul S;Difiore D;Milathianaki D;Fry AR;Miahnahri A;Schafer DW;Messerschmidt M;Seibert MM;Koglin JE;Sokaras D;Weng TC;Sellberg J;Latimer MJ;Grosse-Kunstleve RW;Zwart PH;White WE;Glatzel P;Adams PD;Bogan MJ;Williams GJ;Boutet S;Messinger J;Zouni A;Sauter NK;Yachandra VK;Bergmann U;Yano J
通讯作者：
Yano J
影响因子：
48
作者：
Koopmann, Rudolf;Cupelli, Karolina;Redecke, Lars;Nass, Karol;DePonte, Daniel P.;White, Thomas A.;Stellato, Francesco;Rehders, Dirk;Liang, Mengning;Andreasson, Jakob;Aquila, Andrew;Bajt, Sasa;Barthelmess, Miriam;Barty, Anton;Bogan, Michael J.;Bostedt, Christoph;Boutet, Sebastien;Bozek, John D.;Caleman, Carl;Coppola, Nicola;Davidsson, Jan;Doak, R. Bruce;Ekeberg, Tomas;Epp, Sascha W.;Erk, Benjamin;Fleckenstein, Holger;Foucar, Lutz;Graafsma, Heinz;Gumprecht, Lars;Hajdu, Janos;Hampton, Christina Y.;Hartmann, Andreas;Hartmann, Robert;Hauser, Guenter;Hirsemann, Helmut;Holl, Peter;Hunter, Mark S.;Kassemeyer, Stephan;Kirian, Richard A.;Lomb, Lukas;Maia, Filipe R. N. C.;Kimmel, Nils;Martin, Andrew V.;Messerschmidt, Marc;Reich, Christian;Rolles, Daniel;Rudek, Benedikt;Rudenko, Artem;Schlichting, Ilme;Schulz, Joachim;Seibert, M. Marvin;Shoeman, Robert L.;Sierra, Raymond G.;Soltau, Heike;Stern, Stephan;Strueder, Lothar;Timneanu, Nicusor;Ullrich, Joachim;Wang, Xiaoyu;Weidenspointner, Georg;Weierstall, Uwe;Williams, Garth J.;Wunderer, Cornelia B.;Fromme, Petra;Spence, John C. H.;Stehle, Thilo;Chapman, Henry N.;Betzel, Christian;Duszenko, Michael
通讯作者：
Duszenko, Michael
影响因子：
6.1
作者：
Sauter NK;Poon BK
通讯作者：
Poon BK
DOI：
10.1126/science.1217737
发表时间：
2012-07-20
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Boutet S;Lomb L;Williams GJ;Barends TR;Aquila A;Doak RB;Weierstall U;DePonte DP;Steinbrener J;Shoeman RL;Messerschmidt M;Barty A;White TA;Kassemeyer S;Kirian RA;Seibert MM;Montanez PA;Kenney C;Herbst R;Hart P;Pines J;Haller G;Gruner SM;Philipp HT;Tate MW;Hromalik M;Koerner LJ;van Bakel N;Morse J;Ghonsalves W;Arnlund D;Bogan MJ;Caleman C;Fromme R;Hampton CY;Hunter MS;Johansson LC;Katona G;Kupitz C;Liang M;Martin AV;Nass K;Redecke L;Stellato F;Timneanu N;Wang D;Zatsepin NA;Schafer D;Defever J;Neutze R;Fromme P;Spence JC;Chapman HN;Schlichting I
通讯作者：
Schlichting I
DOI：
10.1107/s0907444912048524
发表时间：
2013-07
期刊：
Acta crystallographica. Section D, Biological crystallography
影响因子：
--
作者：
Powell HR;Johnson O;Leslie AG
通讯作者：
Leslie AG