Long noncoding RNA IL6-AS1 is highly expressed in chronic obstructive pulmonary disease and is associated with interleukin 6 by targeting miR-149-5p and early B-cell factor 1.
Long noncoding RNA IL6-AS1 is highly expressed in chronic obstructive pulmonary disease and is associated with interleukin 6 by targeting miR-149-5p and early B-cell factor 1.
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DOI：
10.1002/ctm2.479
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发表时间：
2021-07
影响因子：
10.6
通讯作者：
Ran P
中科院分区：
文献类型：
--
作者：
Yi E;Zhang J;Zheng M;Zhang Y;Liang C;Hao B;Hong W;Lin B;Pu J;Lin Z;Huang P;Li B;Zhou Y;Ran P
慢性阻塞性肺病是一种复杂的疾病，有多种病因，包括炎症。我们发现了一种新的长链非编码RNA (lncRNA)，白细胞介素6反义RNA 1 (IL6‐AS1)，它在这种疾病中表达上调，并与气道炎症有关。我们发现IL6‐AS1促进炎症因子的表达，尤其是白细胞介素（IL） 6。在机制上，细胞质IL - 6 - AS1通过竞争性地结合microRNA miR - 149 - 5p来稳定IL - 6 mRNA，从而起到内源性海绵的作用。核IL - 6 - AS1通过募集早期B细胞因子1到IL - 6启动子来促进IL - 6转录，从而增加H3K4组蛋白的甲基化和H3K27组蛋白的乙酰化。我们提出了一个lncRNA在细胞核和细胞质中的表达模型，通过不同的机制发挥相似的作用，IL6‐AS1可能通过多种途径增加炎症。该研究提供了新的lncRNA IL6‐AS1在COPD中高表达并与炎症相关的证据。IL - 6‐AS1作为竞争性内源性RNA （ceRNA）与hsa‐miR‐149‐5p竞争性结合，调节IL - 6的表达。IL - 6 - AS1通过将EBF1募集到IL - 6启动子区域来促进基因表达。
Chronic obstructive pulmonary disease is a complex condition with multiple etiologies, including inflammation. We identified a novel long noncoding RNA (lncRNA), interleukin 6 antisense RNA 1 (IL6‐AS1), which is upregulated in this disease and is associated with airway inflammation. We found that IL6‐AS1 promotes the expression of inflammatory factors, especially interleukin (IL) 6. Mechanistically, cytoplasmic IL6‐AS1 acts as an endogenous sponge by competitively binding to the microRNA miR‐149‐5p to stabilize IL‐6 mRNA. Nuclear IL6‐AS1 promotes IL‐6 transcription by recruiting early B‐cell factor 1 to the IL‐6 promoter, which increases the methylation of the H3K4 histone and acetylation of the H3K27 histone. We propose a model of lncRNA expression in both the nucleus and cytoplasm that exerts similar effects through differing mechanisms, and IL6‐AS1 probably increases inflammation via multiple pathways. The study provides the evidence that a novel lncRNA IL6‐AS1 is highly expressed in COPD and is associated with inflammation. IL6‐AS1 acts as the competitive endogenous RNA (ceRNA) to competitively bind to hsa‐miR‐149‐5p to regulate IL‐6 expression. IL6‐AS1 acts as a guide to promote the gene expression via recruiting EBF1 to the region of the IL‐6 promoter.
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影响因子：
11.4
作者：
Armartmuntree N;Murata M;Techasen A;Yongvanit P;Loilome W;Namwat N;Pairojkul C;Sakonsinsiri C;Pinlaor S;Thanan R
通讯作者：
Thanan R
影响因子：
3.6
作者：
Diehl, S;Rincón, M
通讯作者：
Rincón, M
影响因子：
14.2
作者：
Castellucci, Monica;Rossato, Marzia;Bazzoni, Flavia
通讯作者：
Bazzoni, Flavia
DOI：
10.1126/science.1262110
发表时间：
2015-05-08
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
GTEx Consortium
通讯作者：
GTEx Consortium
影响因子：
32.4
作者：
Jego, G;Palucka, AK;Banchereau, J
通讯作者：
Banchereau, J