The impact of preceding noise on the frequency tuning of rat auditory cortex neurons.
The impact of preceding noise on the frequency tuning of rat auditory cortex neurons.
复制标题
前置噪声对大鼠听觉皮层神经元频率调谐的影响
DOI：
10.1186/1471-2202-13-70
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发表时间：
2012-06-18
期刊：
影响因子：
2.4
通讯作者：
Zhang J
中科院分区：
文献类型：
--
作者：
Peng Y;Xing P;He J;Sun X;Zhang J
背景在自然环境中，背景噪声经常与用于检测或区分的信号声音以时间关系发生。然而，在噪声环境中听觉皮层神经元对声音频率的表征还没有完全了解。因此，本研究的目的是探讨背景噪声的影响，以更好地了解皮层频率编码的机制，在一个复杂的声学environment.ResultsWe的皮质调谐信号声音频率的影响进行比较的兴奋性频率水平感受野（FLRFs）的神经元在大鼠初级听觉皮层安静和噪声条件下确定。根据听觉皮层神经元最小阈值和FLRF的变化，我们发现皮层神经元的FLRF受不同的前向噪声的动态调制。当噪声和探测音之间的刺激间隔是恒定的，FLRF的调制随着噪声水平的增加而增加。如果前面的噪声水平是恒定的，调制时，刺激间的时间间隔增加。前噪声使47.6%的被测神经元的前向荧光频率带宽变窄。此外，先前的噪声移动了47.6%的神经元的CFs超过0.25倍频程，而其余的神经元的CFs保持相对不变.ConclusionsThe结果表明，皮质表示的声音频率是动态调制的上下文声学环境，并有皮质神经元的特征频率是抗干扰的上下文噪声。
BackgroundIn a natural environment, contextual noise frequently occurs with a signal sound for detection or discrimination in a temporal relation. However, the representation of sound frequency by auditory cortical neurons in a noisy environment is not fully understood. Therefore, the purpose of this study was to explore the impact of contextual noise on the cortical tuning to signal sound frequency in order to better understand the mechanism of cortical frequency coding in a complex acoustical environment.ResultsWe compared the excitatory frequency-level receptive fields (FLRFs) of neurons in the rat primary auditory cortex determined under both quiet and preceding noise conditions. Based on the changes of minimum threshold and the extent of FLRF of auditory cortical neurons, we found that the FLRFs of a cortical neuron were modulated dynamically by a varying preceding noise. When the interstimulus interval between noise and the probe tone was constant, the modulation of the FLRF increased as the level of noise was increased. If the preceding noise level was constant, the modulation decreased when the interstimulus interval was increased. Preceding noise sharpened the bandwidth of the FLRFs of 47.6% tested neurons. Moreover, preceding noise shifted the CFs of 47.6% neurons by more than 0.25 octaves, while the CFs of the rest of the neurons remained relatively unchanged.ConclusionsThe results indicate that the cortical representation of sound frequency is dynamically modulated by contextual acoustical environment, and that there are cortical neurons whose characteristic frequencies were resistant to the interference of contextual noise.
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影响因子：
25
作者：
Bandyopadhyay, Sharba;Shamma, Shihab A.;Kanold, Patrick O.
通讯作者：
Kanold, Patrick O.
影响因子：
1.8
作者：
Saarela, Toni P.;Herzog, Michael H.
通讯作者：
Herzog, Michael H.
影响因子：
2.5
作者：
Doron, NN;Ledoux, JE;Semple, MN
通讯作者：
Semple, MN
DOI：
10.1523/jneurosci.5359-08.2009
发表时间：
2009-02-25
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Nelson PC;Smith ZM;Young ED
通讯作者：
Young ED
影响因子：
2.8
作者：
Harrison, RV;Kakigi, A;Mount, RJ
通讯作者：
Mount, RJ