Dichotomy of functional organization in the mouse auditory cortex.
Dichotomy of functional organization in the mouse auditory cortex.
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DOI：
10.1038/nn.2490
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发表时间：
2010-03
影响因子：
25
通讯作者：
Kanold, Patrick O.
中科院分区：
文献类型：
--
作者：
Bandyopadhyay, Sharba;Shamma, Shihab A.;Kanold, Patrick O.
大脑皮层的感觉区具有感觉维度的多种地形表征。频率选择性梯度（音调）是初级听觉皮层的主要组织特征，而其他基于特征的组织则不太完善。我们探测的地形组织的小鼠听觉皮层在单细胞水平上使用在体双光子钙离子成像。Tonotopy是目前在大规模，但在一个罚款规模断裂。强度调谐，重要的水平不变的表示，观察到在个别细胞，但没有地形组织。假定的阈下反应的存在或几乎不存在揭示了地形组织的二分法。包括阈下反应揭示了地形聚类的神经元具有相似的响应特性，而这样的集群是不存在的阈上反应。这种二分法表明，具有局部共享输入的邻近神经元组可以在ACX中执行独立的并行计算。
The sensory areas of the cerebral cortex possess multiple topographic representations of sensory dimensions. Gradient of frequency selectivity (tonotopy) is the dominant organizational feature in the primary auditory cortex, while other feature-based organizations are less well established. We probed the topographic organization of the mouse auditory cortex at the single cell level using in vivo two-photon Ca2+ imaging. Tonotopy was present on a large scale but was fractured on a fine scale. Intensity tuning, important in level-invariant representation, was observed in individual cells but was not topographically organized. The presence or near-absence of putative sub-threshold responses revealed a dichotomy in topographic organization. Inclusion of sub-threshold responses revealed a topographic clustering of neurons with similar response properties, while such clustering was absent in supra-threshold responses. This dichotomy indicates that groups of nearby neurons with locally shared inputs can perform independent parallel computations in ACX.
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