What are microarrays teaching us about sleep?
What are microarrays teaching us about sleep?
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DOI：
10.1016/j.molmed.2008.12.002
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发表时间：
2009-02
影响因子：
13.6
通讯作者：
Pack AI
中科院分区：
文献类型：
--
作者：
Mackiewicz M;Zimmerman JE;Shockley KR;Churchill GA;Pack AI
关于睡眠的许多基本问题仍未得到解答。跨门睡眠的存在表明，它必须服务于基本的细胞和/或分子功能。在几个模型系统中进行的微阵列研究已经确定了睡眠状态调节的基因类别。这导致了以下概念：首先，睡眠的功能是维持突触的内稳态；第二，睡眠是大分子生物合成的一个阶段；第三，延长清醒时间会导致一些重要代谢途径的下调；第四，延长清醒时间会导致内质网应激。在人体研究中，微阵列被应用于识别困倦和阻塞性睡眠呼吸暂停的常见衰弱状况的生物标志物。
Many fundamental questions about sleep remain unanswered. The presence of sleep across phyla suggests that it must serve a basic cellular and/or molecular function. Microarray studies, performed in several model systems, have identified classes of genes that are sleep-state regulated. This has led to the following concepts: first, a function of sleep is to maintain synaptic homeostasis; second, sleep is a stage of macromolecule biosynthesis; third, extending wakefulness leads to downregulation of several important metabolic pathways; and, fourth, extending wakefulness leads to endoplasmic reticulum stress. In human studies, microarrays are being applied to the identification of biomarkers for sleepiness and for the common debilitating condition of obstructive sleep apnea.
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