Weight and mid-upper arm circumference gain velocities during treatment of young children with severe acute malnutrition, a prospective study in Uganda.
Weight and mid-upper arm circumference gain velocities during treatment of young children with severe acute malnutrition, a prospective study in Uganda.
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DOI：
10.1186/s40795-021-00428-0
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发表时间：
2021-06-18
期刊：
影响因子：
2
通讯作者：
Grenov B
中科院分区：
文献类型：
--
作者：
Kamugisha JGK;Lanyero B;Nabukeera-Barungi N;Nambuya-Lakor H;Ritz C;Mølgaard C;Michaelsen KF;Briend A;Mupere E;Friis H;Grenov B
在治疗复杂性严重急性营养不良（SAM）儿童期间，常规监测体重增加，以评估水合作用和生长情况。然而，体重和中上臂围（MUAC）的增长速度随时间的变化几乎没有描述。我们通过治疗阶段和水肿状态评估了6 - 59个月患有复杂SAM的儿童的体重和MUAC增加速度。这是一项前瞻性研究，嵌套在随机/益生菌试验（ISRCTN 16454889）中。使用线性混合效应模型，通过治疗阶段和入院时水肿评估体重和MUAC增加速度。在入组的400名儿童中，中位（IQR）年龄为15.0（11.2; 19.2）个月，58%为男性，65%出现水肿。在住院治疗护理（ITC）期间，入院时有水肿与无水肿的儿童在稳定期的体重增加速度为负[第3天和第4天的差异分别为− 11.26（95%CI：− 20.73; − 1.79）g/kg/d和− 13.09（95%CI：− 23.15; − 3.02）g/kg/d]。这逐渐转变为正的体重增加速度，并最终在康复阶段早期达到峰值12 g/kg/d，水肿状态无差异（P> 0.9）。在门诊治疗护理（OTC）期间，总体而言，体重增加速度随时间呈下降趋势（从5至2 g/kg/d），[第2周水肿组和非水肿组之间的差异为2.1（95% CI：1.0; 3.2）g/kg/d]。MUAC增重速度结果反映了增重速度[ITC第1周的差异为− 2.30（95% CI：− 3.6; − 0.97）mm/周，OTC第2周的差异为0.65（95% CI：− 0.07; 1.37）mm/周]。乌干达复杂SAM儿童的体重和MUAC增加速度在过渡期和康复期早期呈增加趋势，此后呈下降趋势，但总体而言，追赶性生长延长。需要进一步的研究来建立特定的截止值，以评估不同康复期间的体重和MUAC增加速度。在线版本包含补充材料，可通过10.1186/s40795 - 021 - 00428 - 0获得。
Weight gain is routinely monitored to assess hydration and growth during treatment of children with complicated severe acute malnutrition (SAM). However, changes in weight and mid-upper arm circumference (MUAC) gain velocities over time are scarcely described. We assessed weight and MUAC gain velocities in 6–59 mo-old children with complicated SAM by treatment phase and edema status. This was a prospective study, nested in a randomized/probiotic trial (ISRCTN16454889). Weight and MUAC gain velocities were assessed by treatment phase and edema at admission using linear mixed-effects models. Among 400 children enrolled, the median (IQR) age was 15.0 (11.2;19.2) months, 58% were males, and 65% presented with edema. During inpatient therapeutic care (ITC), children with edema vs no edema at admission had negative weight gain velocity in the stabilization phase [differences at day 3 and 4 were − 11.26 (95% CI: − 20.73; − 1.79) g/kg/d and − 13.09 (95% CI: − 23.15; − 3.02) g/kg/d, respectively]. This gradually changed into positive weight gain velocity in transition and eventually peaked at 12 g/kg/d early in the rehabilitation phase, with no difference by edema status (P > 0.9). During outpatient therapeutic care (OTC), overall, weight gain velocity showed a decreasing trend over time (from 5 to 2 g/kg/d), [difference between edema and non-edema groups at week 2 was 2.1 (95% CI: 1.0;3.2) g/kg/d]. MUAC gain velocity results mirrored those of weight gain velocity [differences were − 2.30 (95% CI: − 3.6; − 0.97) mm/week at week 1 in ITC and 0.65 (95% CI: − 0.07;1.37) mm/week at week 2 in OTC]. Weight and MUAC gain velocities among Ugandan children with complicated SAM showed an increasing trend during transition and early in the rehabilitation phase, and a decreasing trend thereafter, but, overall, catch-up growth was prolonged. Further research to establish specific cut-offs to assess weight and MUAC gain velocities during different periods of rehabilitation is needed. The online version contains supplementary material available at 10.1186/s40795-021-00428-0.
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影响因子：
3.7
作者：
Atnafe, Binyam;Roba, Kedir Teji;Dingeta, Tariku
通讯作者：
Dingeta, Tariku
影响因子：
168.9
作者：
Black, Robert E.;Victora, Cesar G.;Uauy, Ricardo
通讯作者：
Uauy, Ricardo
影响因子：
7.1
作者：
FJELD, CR;SCHOELLER, DA;BROWN, KH
通讯作者：
BROWN, KH
影响因子：
3.6
作者：
ASHWORTH, A
通讯作者：
ASHWORTH, A
喀麦隆Gado门诊治疗中心的6-59个月儿童患有严重急性营养不良的儿童。
影响因子：
1.8
作者：
Ndzo JA;Jackson A
通讯作者：
Jackson A