Forensic NMR metabolomics: one more arrow in the quiver.

Forensic NMR metabolomics: one more arrow in the quiver.
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法医核磁共振代谢组学:一个箭头在箭头。

DOI:
10.1007/s11306-020-01743-6
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发表时间:
2020-11-07
期刊:
Metabolomics : Official journal of the Metabolomic Society
影响因子:
--
通讯作者:
d'Aloja E
d'Aloja E
中科院分区:
其他
文献类型:
--
作者:
Locci E;Bazzano G;Chighine A;Locco F;Ferraro E;Demontis R;d'Aloja E

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核磁共振代谢组学越来越多地用于法医,因为有可能调查内源性代谢谱和外源性分子,这些分子可能有助于描述代谢模式及其与法医感兴趣的特定条件相关的修饰。这项工作的目的是回顾最近的文献和描述的信息提供核磁共振代谢组学。已将注意力集中在鉴定特殊的代谢特征和特定的死前和死后特征或与法医关注的不同条件有关的生物标志物上,例如鉴定生物痕迹、估计死亡时间和接触滥用药物。所描述的研究结果强调了法医如何从核磁共振代谢组学中获益,通过获得额外的信息,这些信息可能有助于阐明几个仍然值得进一步阐明的法医问题。
NMR metabolomics is increasingly used in forensics, due to the possibility of investigating both endogenous metabolic profiles and exogenous molecules that may help to describe metabolic patterns and their modifications associated to specific conditions of forensic interest. The aim of this work was to review the recent literature and depict the information provided by NMR metabolomics. Attention has been devoted to the identification of peculiar metabolic signatures and specific ante-mortem and post-mortem profiles or biomarkers related to different conditions of forensic concern, such as the identification of biological traces, the estimation of the time since death, and the exposure to drugs of abuse. The results of the described studies highlight how forensics can benefit from NMR metabolomics by gaining additional information that may help to shed light in several forensic issues that still deserve to be further elucidated.
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