Deciphering Potential Correlations between New Biomarkers and Pattern Classification in Chinese Medicine by Bioinformatics: Two Examples of Rheumatoid Arthritis

Deciphering Potential Correlations between New Biomarkers and Pattern Classification in Chinese Medicine by Bioinformatics: Two Examples of Rheumatoid Arthritis
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用生物信息学解读新生物标志物与中医证候分类之间的潜在相关性:类风湿关节炎的两个例子

DOI:
10.1007/s11655-018-2571-8
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发表时间:
2018-10
影响因子:
2.9
通讯作者:
Ai ping Lu
Ai ping Lu
中科院分区:
医学3区
文献类型:
--
作者:
Chi Zhang;Li Li;Ge Zhang;Ke ji Chen;Ai ping Lu

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生物学的复杂性和个性化医疗的需求意味着生物标志物的开发变得越来越具有挑战性。因此,需要创建新的研究范式,将不同的个人分类器集合在一起。一个潜在的解决方案是生物标志物开发和中医模式分类之间的合作。在这篇文章中,类风湿性关节炎的两个例子进行了讨论,包括一个新的生物标志物候选人酪蛋白激酶2相互作用蛋白1(CKIP-1)和微小RNA 214。作者获得了生物标志物鉴定中疾病模式分类的“快照”。生物信息学分析表明,两个候选生物标志物的潜在生物学功能与类风湿关节炎的中医证型有不同程度的相关性。作者的初步尝试可以为研究生物标志物与中医证型之间的双赢潜在相关性提供一个新的窗口。
Biological complexity and the need for personalized medicine means that biomarker development has become increasingly challenging. Thus, new paradigms for research need to be created that bring together a different classifier of individuals. One potential solution is collaboration between biomarker development and Chinese medicine pattern classification. In this article, two examples of rheumatoid arthritis are discussed, including a new biomarker candidate casein kinase 2 interacting protein 1 (CKIP-1) and a micro RNA 214. The authors obtained a “snapshot” of pattern classification with disease in biomarker identification. Bioinformatics analyses revealed underlying biological functions of two biomarker candidates, in varying degrees, are correlated with Chinese medicine pattern of rheumatoid arthritis. The authors’ initial attempt can provide a new window for studying the win-win potential correlation between the biomarkers and pattern classification in Chinese medicine.
DOI: 10.1155/2012/203043
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