Aortic arch calcification predicts the renal function progression in patients with stage 3 to 5 chronic kidney disease.
Aortic arch calcification predicts the renal function progression in patients with stage 3 to 5 chronic kidney disease.
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DOI：
10.1155/2015/131263
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发表时间：
2015
影响因子：
--
通讯作者：
Lee CT
中科院分区：
文献类型：
--
作者：
Li LC;Lee YT;Lee YW;Chou CA;Lee CT
介绍。胸片显示主动脉弓钙化（AoAC）和心脏肥大已被证明是慢性肾病（CKD）患者心血管死亡的重要危险因素。然而，AoAC、心脏扩大和肾功能进展之间的相互关系仍不清楚。本研究的目的是评估 AoAC 和心脏扩大是否与 3-5 期 CKD 患者的肾功能进展独立相关。方法。我们通过胸部 X 线检查回顾性确定 237 例患者是否有 AoAC 和心脏扩大，随访至少三年，未进入透析，并根据是否存在 AoAC 和心脏扩大分为 4 组。肾功能的变化通过估计肾小球滤过率（eGFR）的斜率来测量。结果。在 237 名患者中，AoAC 和心脏肥大共存组的 eGFR 下降率显着高于其他组。基线 AoAC 和蛋白尿与 eGFR 下降独立相关。 AoAC 由年龄、eGFR 斜率和心脏肥大独立确定。结论。 AoAC 和心脏扩大的共存与 eGFR 更快下降有关。 AoAC 是 CKD 3-5 期患者肾脏结局的独立决定因素。
Introduction. The presence of aortic arch calcification (AoAC) and cardiomegaly on chest radiography has been demonstrated as important risk factors for cardiovascular mortality in patients with chronic kidney disease (CKD). However, the interrelationship among AoAC, cardiomegaly, and renal function progression remains unclear. The aim of this study is to assess whether AoAC and cardiomegaly are independently associated with the renal function progression in patients with stages 3–5 CKD. Methods. We retrospectively determined AoAC and cardiomegaly by chest X-ray in 237 patients, followed up for at least three years without entering dialysis and classified into 4 groups according to the presence or absence of AoAC and cardiomegaly. The change in renal function was measured by the slope of estimated glomerular filtration rate (eGFR). Results. Of the 237 patients, the rate of eGFR decline was significantly higher in the group with coexistence of AoAC and cardiomegaly than any other groups. Baseline AoAC and proteinuria were independently associated with eGFR decline. AoAC were independently determined by age, eGFR slope, and cardiomegaly. Conclusions. The coexistence of AoAC and cardiomegaly is associated with faster eGFR decline. AoAC is an independent determinant of renal outcomes in patients with CKD stages 3–5.
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影响因子：
8.3
作者：
Ford, Martin L.;Tomlinson, Laurie A.;Holt, Stephen G.
通讯作者：
Holt, Stephen G.
影响因子：
3.3
作者：
Fujiu, Ayuko;Cigawa, Tetsuya;Nitta, Kosaku
通讯作者：
Nitta, Kosaku
影响因子：
1.3
作者：
Ogawa, Tetsuya;Ishida, Hideki;Nitta, Kosaku
通讯作者：
Nitta, Kosaku
DOI：
10.2215/cjn.02350213
发表时间：
2013-11-07
影响因子：
9.8
作者：
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通讯作者：
Chen, Hung-Chun
影响因子：
8.3
作者：
O'Rourke, MF;Safar, ME
通讯作者：
Safar, ME