Smart biomaterial platforms: Controlling and being controlled by cells.
Smart biomaterial platforms: Controlling and being controlled by cells.
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DOI：
10.1016/j.biomaterials.2022.121450
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发表时间：
2022-04
期刊：
影响因子：
14
通讯作者：
Henderson JH
中科院分区：
文献类型：
--
作者：
Narkar AR;Tong Z;Soman P;Henderson JH
在不同的研究和应用领域，动态功能，如生物化学性质，机械性能，或在微观或宏观结构的可编程变化是一个越来越常见的生物材料设计标准，加入长期研究的标准，如细胞相容性和生物相容性，药物释放动力学，可控的降解性或长期稳定性在体内。尽管付出了巨大的努力，实现动态功能，同时保持其他所需的设计标准仍然是一个重大的挑战。可逆动态功能，而不是一次性或单向动态功能，特别令人感兴趣，但已被证明特别具有挑战性。这种可逆的功能性可以使研究能够解决体内生物学和生物力学过程的动态性质（例如细胞牵引、细胞-细胞外基质（ECM）相互作用和细胞介导的ECM重塑）与用于研究所述过程的底物和ECM构建体的静态性质之间的当前差距。这篇综述评估了传统上用于控制细胞活性和静态生物材料结构的动态材料，实验和计算技术，其特征可能会告知可逆动态材料的持续进展。总之，这篇综述提出了一个观点，结合智能材料的可逆性和静态聚合物探测的深入动态细胞行为，设计智能双向ECM平台，可以可逆地和重复地与细胞通信。
Across diverse research and application areas, dynamic functionality—such as programmable changes in biochemical property, in mechanical property, or in microscopic or macroscopic architecture—is an increasingly common biomaterials design criterion, joining long-studied criteria such as cytocompatibility and biocompatibility, drug release kinetics, and controlled degradability or long-term stability in vivo. Despite tremendous effort, achieving dynamic functionality while simultaneously maintaining other desired design criteria remains a significant challenge. Reversible dynamic functionality, rather than one-time or one-way dynamic functionality, is of particular interest but has proven especially challenging. Such reversible functionality could enable studies that address the current gap between the dynamic nature of in vivo biological and biomechanical processes, such as cell traction, cell-extracellular matrix (ECM) interactions, and cell-mediated ECM remodeling, and the static nature of the substrates and ECM constructs used to study the processes. This review assesses dynamic materials that have traditionally been used to control cell activity and static biomaterial constructs, experimental and computational techniques, with features that may inform continued advances in reversible dynamic materials. Taken together, this review presents a perspective on combining the reversibility of smart materials and the in-depth dynamic cell behavior probed by static polymers to design smart bi-directional ECM platforms that can reversibly and repeatedly communicate with cells.
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影响因子：
10
作者：
Abdeen, Amr A.;Lee, Junmin;Bharadwaj, N. Ashwin;Ewoldt, Randy H.;Kilian, Kristopher A.
通讯作者：
Kilian, Kristopher A.
DOI：
10.1039/c6ib00027d
发表时间：
2016-06-13
期刊：
Integrative biology : quantitative biosciences from nano to macro
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影响因子：
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作者：
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影响因子：
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作者：
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