Hormone replacement therapy in perimenopausal women and 2-year change of carotid intima-media thickness.
Hormone replacement therapy in perimenopausal women and 2-year change of carotid intima-media thickness.
复制标题
围绝经期妇女的激素替代治疗和颈动脉内膜中层厚度的 2 年变化。
DOI：
10.1016/s0378-5122(99)00035-3
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发表时间：
1999
期刊：
影响因子：
4.9
通讯作者：
D. Grobbee
中科院分区：
文献类型：
--
作者：
M. J. D. Kleijn;M. Bots;M. Bots;Annette A.A. Bak;I. Westendorp;J. Planellas;H. Bennink;J. Witteman;D. Grobbee;D. Grobbee
目的评估口服17 β-雌二醇和去氧孕烯（17 β E-D）联合治疗方案和共轭马雌激素和炔诺孕酮（CEE-N）序贯联合治疗方案与安慰剂相比对围绝经期妇女颈总动脉内膜中层厚度和舒张末期管腔直径的2年影响。17 β E-D和安慰剂组为双盲研究，CEE-N为开放研究。第6周期后，揭盲，活性研究组的试验作为开放试验继续进行18个月。该研究包括从普通人群中招募的121名围绝经期妇女。颈总动脉内膜中层厚度和舒张末期管腔直径分别在基线和周期24与B-模式ultrasonography. ResultsAt周期24内膜中层厚度和管腔直径的小变化进行了观察。相对于安慰剂，17 β E-D和CEE-N的内膜-中层厚度变化分别为− 0.009 mm [95% CI − 0.045; 0.027]和− 0.016 mm [95% CI − 0.055; 0.024]。对于舒张末期管腔直径，17 β E-D和CEE-N的变化分别为-0.091 mm [95%CI-0.236; 0.055]和-0.125 mm [95%CI-0.820; 0.032]。虽然本试验的样本量太有限，无法提供明确的结论，但效果的方向与早期关于激素替代疗法对绝经后妇女影响的研究证据一致。
ObjectivesTo assess the 2-year effects of a combined regimen of oral 17β-estradiol and desogestrel (17βE-D) and a sequential combination of conjugated equine estrogens and norgestrel (CEE-N) on common carotid intima-media thickness and end-diastolic lumen diameter in comparison to placebo in perimenopausal women.MethodsThe study was a single center, randomized, group-comparative, double-blind study with respect to the 17βE-D and placebo groups and open with respect to CEE-N. After cycle 6, the blind was broken and the trial was continued as an open trial for another 18 months for the active study arms. The study included 121 perimenopausal women recruited from the general population. Common carotid intima-media thickness and end-diastolic lumen diameter were measured at baseline and cycle 24 with B-mode ultrasonography.ResultsAt cycle 24 small changes in intima-media thickness and lumen diameter were observed. Relative to placebo, changes in intima-media thickness were −0.009 mm [95% CI −0.045; 0.027] for 17βE-D and −0.016 mm [95% CI −0.055; 0.024] for CEE-N. For end-diastolic lumen diameter the changes were −0.091 mm [95% CI −0.236; 0.055] and −0.125 mm [95% CI −0.820; 0.032] for 17βE-D and CEE-N, respectively.ConclusionsIn this study among perimenopausal women a significant effect of 17βE-D and CEE-N on common carotid intima-media thickness and lumen diameter could not be demonstrated. Although the sample size of the present trial is too limited to provide definite conclusions, the direction of the effect is in agreement with evidence from earlier studies on the effects of hormone replacement therapy in postmenopausal women.
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DOI：
10.1161/01.atv.10.6.1051
发表时间：
1990-11-01
期刊：
ARTERIOSCLEROSIS
影响因子：
--
作者：
ADAMS, MR;KAPLAN, JR;CLARKSON, TB
通讯作者：
CLARKSON, TB
影响因子：
5
作者：
HEISS, G;SHARRETT, AR;ALZOLA, C
通讯作者：
ALZOLA, C
影响因子：
120.7
作者：
PSATY, BM;FURBERG, CD;REID, C
通讯作者：
REID, C
绝经和激素替代治疗与颈动脉内膜中层厚度没有关联。
影响因子：
37.8
作者：
Nabulsi,AA;Folsom,AR;Szklo,M;White,A;Higgins,M;Heiss,G
通讯作者：
Heiss,G