Neural activation during anticipated peer evaluation and laboratory meal intake in overweight girls with and without loss of control eating.
Neural activation during anticipated peer evaluation and laboratory meal intake in overweight girls with and without loss of control eating.
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DOI：
10.1016/j.neuroimage.2014.12.054
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发表时间：
2015-03
期刊：
影响因子：
5.7
通讯作者：
Yanovski JA
中科院分区：
文献类型：
--
作者：
Jarcho JM;Tanofsky-Kraff M;Nelson EE;Engel SG;Vannucci A;Field SE;Romer AL;Hannallah L;Brady SM;Demidowich AP;Shomaker LB;Courville AB;Pine DS;Yanovski JA
饮食失控的人际关系模型提出，社交困境会导致焦虑状态，从而引发过度的食物消费。自我报告支持这些联系，但这些关系的神经生物学基础仍然不清楚。因此，我们在实验室中研究了与焦虑有关的大脑区域，这些区域与饮食和能量摄入有关。22名超重和肥胖（BMIz：1.9±0.4）的青少年（15.8± 1.6岁）女孩，在模拟同伴互动聊天室范例中接受功能磁共振成像（fMRI）检查，其中10名超重和肥胖（BMIz：1.9 ± 0.4）的青少年（15.8± 1.6岁）有暴食症（BMIz+，n = 10），12名无暴食症（BMIz-，n=12）。在功能磁共振成像扫描后，女孩们立即从10，934千卡的实验室自助餐中随意食用午餐，并指示“让自己去吃，想吃多少就吃多少”。测试了关于五个感兴趣区域激活的预先指定的假设。对功能磁共振成像数据的分析显示，在腹内侧前额叶皮层（vmPFC）中存在显著的同伴反馈互动，例如，在同伴拒绝后（与接受相比），“+”的活动减少，而“-”的活动增加（p <.005）。此外，vmPFC和纹状体之间的同伴拒绝（与接受）功能耦合与情绪状态相互作用：耦合对情绪+是阳性的，但对情绪-是阴性的（p <0.005）。在高价值同伴的负面同伴反馈期间，梭状回面部区域（FFA）的活动也与抑郁状态相互作用（p <0.005）。FFA激活和进餐时的摄入量之间的正相关性仅在进食量少的人群中观察到。总之，超重和肥胖的女孩与暴食的区别可能是未能从事区域的前额叶皮层参与情绪调节，以应对社会困境。FFA激活和食物摄入之间的关系支持这样一种观点，即对传入的人际线索和社会情绪神经回路扰动的敏感性提高可能导致暴饮暴食，以科普易受影响的青少年因社交不适而引起的负面影响。
The interpersonal model of loss of control (LOC) eating proposes that socially distressing situations lead to anxious states that trigger excessive food consumption. Self-reports support these links, but the neurobiological underpinnings of these relationships remain unclear. We therefore examined brain regions associated with anxiety in relation to LOC eating and energy intake in the laboratory. Twenty-two overweight and obese (BMIz: 1.9±0.4) adolescent (15.8±1.6y) girls with LOC eating (LOC+, n=10) and without LOC eating (LOC−, n=12) underwent functional magnetic resonance imaging (fMRI) during a simulated peer interaction chatroom paradigm. Immediately after the fMRI scan, girls consumed lunch ad libitum from a 10,934-kcal laboratory buffet meal with the instruction to “let yourself go and eat as much as you want.” Pre-specified hypotheses regarding activation of five regions of interest were tested. Analysis of fMRI data revealed a significant group by peer feedback interaction in the ventromedial prefrontal cortex (vmPFC), such that LOC+ had less activity following peer rejection (vs. acceptance), while LOC− had increased activity (p <.005). Moreover, functional coupling between vmPFC and striatum for peer rejection (vs. acceptance) interacted with LOC status: coupling was positive for LOC+, but negative in LOC− (p <.005). Activity of fusiform face area (FFA) during negative peer feedback from high-value peers also interacted with LOC status (p < .005). A positive association between FFA activation and intake during the meal was observed among only those with LOC eating. In conclusion, overweight and obese girls with LOC eating may be distinguished by a failure to engage regions of prefrontal cortex implicated in emotion regulation in response to social distress. The relationship between FFA activation and food intake supports the notion that heightened sensitivity to incoming interpersonal cues and perturbations in socio-emotional neural circuits may lead to overeating in order to cope with negative affect elicited by social discomfort in susceptible youth.
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