Mechanically robust, negative-swelling, mussel-inspired tissue adhesives.
Mechanically robust, negative-swelling, mussel-inspired tissue adhesives.
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DOI：
10.1002/adhm.201200316
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发表时间：
2013-05
影响因子：
10
通讯作者：
Messersmith, Phillip B.
中科院分区：
文献类型：
--
作者：
Barrett, Devin G.;Bushnell, Grace G.;Messersmith, Phillip B.
大多数合成聚合物水凝胶组织粘合剂和密封剂在生理条件下会大幅膨胀，这可能导致机械减弱和不良的医疗并发症。在此，我们描述了基于儿茶酚改性的两亲性聚环氧丙烷-聚环氧乙烷嵌段共聚物的机械坚韧的零膨胀或负膨胀贻贝启发的手术粘合剂的合成和表征。对所得热敏凝胶的形成、溶胀、整体机械和组织粘合性能进行了表征。在室温或低于室温的条件下，儿茶酚氧化迅速形成化学交联网络，随后升温至生理温度，诱导 PPO 结构域发生热疏水转变，并提供体积减小和机械增韧的机制。所描述的方法可以很容易地适用于其他热敏嵌段共聚物和交联策略，代表了可用于控制溶胀和增强医疗环境中使用的聚合物水凝胶的机械性能的通用方法。
Most synthetic polymer hydrogel tissue adhesives and sealants swell considerably in physiologic conditions, which can result in mechanical weakening and adverse medical complications. Herein, we describe the synthesis and characterization of mechanically tough zero- or negative-swelling mussel-inspired surgical adhesives based on catechol-modified amphiphilic poly(propylene oxide)-poly(ethylene oxide) block copolymers. The formation, swelling, bulk mechanical, and tissue adhesive properties of the resulting thermosensitive gels were characterized. Catechol oxidation at or below room temperature rapidly resulted in a chemically cross-linked network, with subsequent warming to physiological temperature inducing a thermal hydrophobic transition in the PPO domains and providing a mechanism for volumetric reduction and mechanical toughening. The described approach can be easily adapted for other thermally sensitive block copolymers and cross-linking strategies, representing a general approach that can be employed to control swelling and enhance mechanical properties of polymer hydrogels used in a medical context.
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影响因子：
6.2
作者：
Huang, K;Lee, BP;Messersmith, PB
通讯作者：
Messersmith, PB
影响因子：
14
作者：
Brubaker, Carrie E.;Kissler, Hermann;Wang, Ling-Jia;Kaufman, Dixon B.;Messersmith, Phillip B.
通讯作者：
Messersmith, Phillip B.
影响因子：
6.2
作者：
Garty, Shai;Kimelman-Bleich, Nadav;Gazit, Dan
通讯作者：
Gazit, Dan
DOI：
10.1016/j.nano.2011.01.017
发表时间：
2011-10-01
影响因子：
5.4
作者：
Chiappetta, Diego A.;Facorro, Graciela;Sosnik, Alejandro
通讯作者：
Sosnik, Alejandro
影响因子：
--
作者：
Glickman, M;Gheissari, A;Ballard, JL
通讯作者：
Ballard, JL