An animal model to evaluate skin-implant-bone integration and gait with a prosthesis directly attached to the residual limb.
An animal model to evaluate skin-implant-bone integration and gait with a prosthesis directly attached to the residual limb.
复制标题
DOI：
10.1016/j.clinbiomech.2013.12.014
复制
发表时间：
2014-03
期刊：
影响因子：
--
通讯作者：
Pitkin M
中科院分区：
文献类型：
--
作者：
Farrell BJ;Prilutsky BI;Kistenberg RS;Dalton JF 4th;Pitkin M
尽管骨锚定假体有许多优点，但由于缺乏完整的皮肤-植入物整合，它们在患者中的使用受到限制。本研究的目的是开发一种动物模型，该模型允许对骨锚定肢体假体的步态进行详细研究，并在站立和行走期间植入物的生理负荷后对皮肤-植入物-骨界面进行组织学分析。记录并分析了两只猫在经皮多孔钛支架植入右胫骨并连接假体之前和之后的全身行走力学。康复程序包括初始肢体铸造，逐步增加植入物的负载，站立和运动训练。在研究结束时，对骨和皮肤长入植入物进行了详细的组织学分析。这两只动物采用骨锚定假体站立和运动，虽然在行走过程中假肢上的负载分别下降了22%和62%，植入后4个月。动物将体重转移到对侧，并增加对侧后肢的推进力。肢体植入物的组织学分析证实了骨和皮肤长入。开发的研究假体步态和组织与植入物整合的动物模型表明，多孔钛植入物可允许骨和皮肤整合以及假体步态。该模型的未来研究将有助于优化种植体和假体性能。
Despite the number of advantages of bone-anchored prostheses, their use in patients is limited due to the lack of complete skin-implant integration. The objective of the present study was to develop an animal model that would permit both detailed investigations of gait with a bone-anchored limb prosthesis and histological analysis of the skin-implant-bone interface after physiological loading of the implant during standing and walking. Full-body mechanics of walking in two cats was recorded and analyzed before and after implantation of a percutaneous porous titanium pylon into the right tibia and attachment of a prosthesis. The rehabilitation procedures included initial limb casting, progressively increasing loading of implant, and standing and locomotor training. Detailed histological analysis of bone and skin ingrowth into implant was performed at the end of the study. The two animals adopted the bone-anchored prosthesis for standing and locomotion, although loads on the prosthetic limb during walking decreased by 22% and 62%, respectively, 4 months after implantation. The animals shifted body weight to the contralateral side and increased propulsion forces by the contralateral hindlimb. Histological analysis of the limb implants demonstrated bone and skin ingrowth. The developed animal model to study prosthetic gait and tissue integration with the implant demonstrated that porous titanium implants may permit bone and skin integration and prosthetic gait with a prosthesis. Future studies with this model will help optimize the implant and prosthesis properties.
登录
查看更多内容
影响因子：
2.4
作者：
D'Angeli, V.;Belvedere, C.;Leardini, A.
通讯作者：
Leardini, A.
影响因子：
1.5
作者：
Frossard, Laurent Alain;Tranberg, Roy;Branemark, Rickard
通讯作者：
Branemark, Rickard
影响因子：
1.5
作者：
Hagberg, K;Häggström, E;Brånemark, R
通讯作者：
Brånemark, R
影响因子：
1.8
作者：
Drygas, Kevin A.;Taylor, Robert;McAlexander, Heather
通讯作者：
McAlexander, Heather
影响因子：
4.9
作者：
Chou, Teri G. Rosenbaum;Petti, Cathy A.;Bloebaum, Roy D.
通讯作者：
Bloebaum, Roy D.