The genomic landscape of prostate cancer.
The genomic landscape of prostate cancer.
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DOI：
10.3390/ijms140610822
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发表时间：
2013-05-24
影响因子：
5.6
通讯作者：
Claessens F
中科院分区：
文献类型：
--
作者：
Spans L;Clinckemalie L;Helsen C;Vanderschueren D;Boonen S;Lerut E;Joniau S;Claessens F
到80岁时，大约80%的男性将在其前列腺内表现出一些癌细胞，这表明前列腺癌构成了主要的健康负担。虽然这种疾病在大多数男性的临床上是微不足道的，但在其他人身上可能会变得致命。对于临床医生来说，最具挑战性的任务是开发一种为患者量身定做的治疗方法，因为他们知道这种疾病具有高度的异质性，而且相对较少有足够的预后工具来区分侵袭性和惰性疾病。下一代测序允许以前所未有的详细程度和不同水平对癌症进行描述，从全基因组或外显子组测序到转录组分析和甲基化特异性免疫沉淀，然后进行测序。所有这些数据的整合有助于更好地理解前列腺癌的发生、发展和转移过程。最终，这些见解将为前列腺癌患者带来更好和更个性化的治疗。本文综述了从高通量研究中获得的拷贝数变化、基因融合、单核苷酸突变和多态、甲基化、microRNAs和长非编码RNAs等方面的知识。
By the age of 80, approximately 80% of men will manifest some cancerous cells within their prostate, indicating that prostate cancer constitutes a major health burden. While this disease is clinically insignificant in most men, it can become lethal in others. The most challenging task for clinicians is developing a patient-tailored treatment in the knowledge that this disease is highly heterogeneous and that relatively little adequate prognostic tools are available to distinguish aggressive from indolent disease. Next-generation sequencing allows a description of the cancer at an unprecedented level of detail and at different levels, going from whole genome or exome sequencing to transcriptome analysis and methylation-specific immunoprecipitation, followed by sequencing. Integration of all these data is leading to a better understanding of the initiation, progression and metastatic processes of prostate cancer. Ultimately, these insights will result in a better and more personalized treatment of patients suffering from prostate cancer. The present review summarizes current knowledge on copy number changes, gene fusions, single nucleotide mutations and polymorphisms, methylation, microRNAs and long non-coding RNAs obtained from high-throughput studies.
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影响因子：
30.8
作者：
Carver, Brett S.;Tran, Jennifer;Gopalan, Anuradha;Chen, Zhenbang;Shaikh, Safa;Carracedo, Arkaitz;Alimonti, Andrea;Nardella, Caterina;Varmeh, Shohreh;Scardino, Peter T.;Cordon-Cardo, Carlos;Gerald, William;Pandolfi, Pier Paolo
通讯作者：
Pandolfi, Pier Paolo
影响因子：
45.3
作者：
Cooperberg, MR;Moul, JW;Carroll, PR
通讯作者：
Carroll, PR
DOI：
10.1073/pnas.0910668107
发表时间：
2010-05-25
影响因子：
11.1
作者：
Ahmadiyeh, Nasim;Pomerantz, Mark M.;Freedman, Matthew L.
通讯作者：
Freedman, Matthew L.
影响因子：
17.1
作者：
Aryee MJ;Liu W;Engelmann JC;Nuhn P;Gurel M;Haffner MC;Esopi D;Irizarry RA;Getzenberg RH;Nelson WG;Luo J;Xu J;Isaacs WB;Bova GS;Yegnasubramanian S
通讯作者：
Yegnasubramanian S
影响因子：
64.8
作者：
Berger, Michael F.;Lawrence, Michael S.;Demichelis, Francesca;Drier, Yotam;Cibulskis, Kristian;Sivachenko, Andrey Y.;Sboner, Andrea;Esgueva, Raquel;Pflueger, Dorothee;Sougnez, Carrie;Onofrio, Robert;Carter, Scott L.;Park, Kyung;Habegger, Lukas;Ambrogio, Lauren;Fennell, Timothy;Parkin, Melissa;Saksena, Gordon;Voet, Douglas;Ramos, Alex H.;Pugh, Trevor J.;Wilkinson, Jane;Fisher, Sheila;Winckler, Wendy;Mahan, Scott;Ardlie, Kristin;Baldwin, Jennifer;Simons, Jonathan W.;Kitabayashi, Naoki;MacDonald, Theresa Y.;Kantoff, Philip W.;Chin, Lynda;Gabriel, Stacey B.;Gerstein, Mark B.;Golub, Todd R.;Meyerson, Matthew;Tewari, Ashutosh;Lander, Eric S.;Getz, Gad;Rubin, Mark A.;Garraway, Levi A.
通讯作者：
Garraway, Levi A.