Gastrodin protects against chronic inflammatory pain by inhibiting spinal synaptic potentiation.
Gastrodin protects against chronic inflammatory pain by inhibiting spinal synaptic potentiation.
复制标题
天麻素通过抑制脊髓突触增强来预防慢性炎症疼痛。
DOI：
10.1038/srep37251
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发表时间：
2016-11-17
影响因子：
4.6
通讯作者：
Luo C
中科院分区：
文献类型：
--
作者：
Xiao MM;Zhang YQ;Wang WT;Han WJ;Lin Z;Xie RG;Cao Z;Lu N;Hu SJ;Wu SX;Dong H;Luo C
众所周知，组织损伤会产生炎症和疼痛。外周伤害性感受器和脊髓板层I神经元之间的突触增强被认为是慢性炎症性疼痛的触发因素。天麻素是中草药天麻的主要活性成分，自古以来就被广泛用作止痛药。然而，其潜在的细胞机制仍然难以捉摸。本研究首次证实天麻素在脊髓水平对外周炎症引起的自发性疼痛、机械性和热性痛觉过敏具有镇痛作用，且不依赖阿片受体，无耐受性。天麻素的这种镇痛作用至少部分是通过阻断酸敏感离子通道抑制脊髓突触增强而实现的。进一步利用微型EPSCs和配对脉搏比分析揭示了天麻素作用的突触前起源，这涉及到递质释放概率的降低。相反，基础伤害性感受和基础突触传递都没有改变。本研究揭示了天麻素对炎性疼痛的显著镇痛作用，揭示了天麻素镇痛的一种新的脊髓机制，为治疗慢性炎症性疼痛提供了一条新的途径。
Tissue injury is known to produce inflammation and pain. Synaptic potentiation between peripheral nociceptors and spinal lamina I neurons has been proposed to serve as a trigger for chronic inflammatory pain. Gastrodin is a main bioactive constituent of the traditional Chinese herbal medicine Gastrodia elata Blume, which has been widely used as an analgesic since ancient times. However, its underlying cellular mechanisms have remained elusive. The present study demonstrated for the first time that gastrodin exhibits an analgesic effect at the spinal level on spontaneous pain, mechanical and thermal pain hypersensitivity induced by peripheral inflammation, which is not dependent on opioid receptors and without tolerance. This analgesia by gastrodin is at least in part mediated by depressing spinal synaptic potentiation via blockade of acid-sensing ion channels. Further studies with miniature EPSCs and paired-pulse ratio analysis revealed the presynaptic origin of the action of gastrodin, which involves a decrease in transmitter release probability. In contrast, neither basal nociception nor basal synaptic transmission was altered. This study revealed a dramatic analgesic action of gastrodin on inflammatory pain and uncovered a novel spinal mechanism that could underlie the analgesia by gastrodin, pointing the way to a new analgesic for treating chronic inflammatory pain.
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DOI：
10.1155/2013/514095
发表时间：
2013
期刊：
Evidence-based complementary and alternative medicine : eCAM
影响因子：
--
作者：
Kumar H;Kim IS;More SV;Kim BW;Bahk YY;Choi DK
通讯作者：
Choi DK
影响因子：
56.9
作者：
Ikeda, Hiroshi;Stark, Johanna;Sandkuhler, Jurgen
通讯作者：
Sandkuhler, Jurgen
影响因子：
11.4
作者：
Deval, Emmanuel;Noel, Jacques;Lingueglia, Eric
通讯作者：
Lingueglia, Eric
影响因子：
4
作者：
Sandkuehler, Juergen;Gruber-Schoffnegger, Doris
通讯作者：
Gruber-Schoffnegger, Doris
影响因子：
64.5
作者：
Basbaum AI;Bautista DM;Scherrer G;Julius D
通讯作者：
Julius D