An Overview of Nanocarrier-Based Adjuvants for Vaccine Delivery.
An Overview of Nanocarrier-Based Adjuvants for Vaccine Delivery.
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DOI：
10.3390/pharmaceutics13040455
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发表时间：
2021-03-27
期刊：
影响因子：
5.4
通讯作者：
Saleem IY
中科院分区：
文献类型：
--
作者：
Petkar KC;Patil SM;Chavhan SS;Kaneko K;Sawant KK;Kunda NK;Saleem IY
疫苗的发展是最重大的医学成就之一，帮助根除了大量疾病。它经历了从减毒活病原体疫苗到杀死整个生物体或灭活毒素(类毒素)的演变过程，每种疫苗都有自己的优缺点。疫苗接种的关键参数是记忆反应的产生和对感染的保护，而一个重要的方面是以智能的方式有效地传递抗原，以唤起强大的免疫反应。在这方面，纳米技术正在极大地促进开发高效的疫苗佐剂和输送系统。它们可以保护被包裹的抗原不受宿主体内环境的影响，并以持续的方式释放它，从而诱导长期的免疫刺激效应。有鉴于此，本文综述了纳米佐剂和载体，如病毒载体、病毒样颗粒和病毒体；非病毒载体，即纳米乳剂、脂类纳米载体、可生物降解和不可降解的纳米颗粒、磷酸钙纳米颗粒、胶体稳定的纳米颗粒、蛋白小体；以及模式识别受体，包括c型凝集素受体和Toll样受体。
The development of vaccines is one of the most significant medical accomplishments which has helped to eradicate a large number of diseases. It has undergone an evolutionary process from live attenuated pathogen vaccine to killed whole organisms or inactivated toxins (toxoids), each of them having its own advantages and disadvantages. The crucial parameters in vaccination are the generation of memory response and protection against infection, while an important aspect is the effective delivery of antigen in an intelligent manner to evoke a robust immune response. In this regard, nanotechnology is greatly contributing to developing efficient vaccine adjuvants and delivery systems. These can protect the encapsulated antigen from the host’s in-vivo environment and releasing it in a sustained manner to induce a long-lasting immunostimulatory effect. In view of this, the present review article summarizes nanoscale-based adjuvants and delivery vehicles such as viral vectors, virus-like particles and virosomes; non-viral vectors namely nanoemulsions, lipid nanocarriers, biodegradable and non-degradable nanoparticles, calcium phosphate nanoparticles, colloidally stable nanoparticles, proteosomes; and pattern recognition receptors covering c-type lectin receptors and toll-like receptors.
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影响因子：
6.2
作者：
Bode C;Zhao G;Steinhagen F;Kinjo T;Klinman DM
通讯作者：
Klinman DM
DOI：
10.1179/096805106x118753
发表时间：
2006-10-01
期刊：
JOURNAL OF ENDOTOXIN RESEARCH
影响因子：
--
作者：
Alderson, Mark R.;McGowan, Patrick;Probst, Peter
通讯作者：
Probst, Peter
影响因子：
7.3
作者：
Awate S;Babiuk LA;Mutwiri G
通讯作者：
Mutwiri G
影响因子：
5.4
作者：
Bulbake U;Doppalapudi S;Kommineni N;Khan W
通讯作者：
Khan W
影响因子：
5.6
作者：
Chabeda, Mayo;van Zyl, Albertha R.;Hitzeroth, Inga I.
通讯作者：
Hitzeroth, Inga I.