Erythrocyte long-chain omega-3 fatty acid levels are inversely associated with mortality and with incident cardiovascular disease: The Framingham Heart Study.
Erythrocyte long-chain omega-3 fatty acid levels are inversely associated with mortality and with incident cardiovascular disease: The Framingham Heart Study.
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DOI：
10.1016/j.jacl.2018.02.010
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发表时间：
2018-05
影响因子：
4.4
通讯作者：
Vasan RS
中科院分区：
文献类型：
--
作者：
Harris WS;Tintle NL;Etherton MR;Vasan RS
omega-3脂肪酸状态与任何原因导致的死亡风险和心血管疾病（CVD）事件的相关程度仍然存在争议。在心脏病研究中检查这些关联。前瞻性和观察性。心脏病研究后代队列。暴露标志物是在基线测量的二十碳五烯酸和二十二碳六烯酸的红细胞水平（Omega-3指数）。结局包括基线时无CVD的受试者的死亡率（总死亡率、CVD、癌症和其他）和总CVD事件。平均随访时间为7.3年。考克斯比例风险模型调整了18个变量（人口统计学、临床状态、治疗和CVD风险因素）。在2500名参与者（平均年龄66岁，54%为女性）中，有350人死亡（58人死于CVD，146人死于癌症，128人死于其他已知原因，18人死于未知原因）。共发生245起CVD事件。在多变量校正分析中，较高的Omega-3指数与总死亡率（P = 0.02）、非CVD和非癌症死亡率（P = 0.009）和总CVD事件（P = 0.008）的风险显著降低（五分位数趋势P值）相关。与Omega-3指数最低的五分之一人群（<4.2%）相比，Omega-3指数最高的人群（>6.8%）因任何原因死亡的风险降低了34%，心血管事件的风险降低了39%。这些协会一般更强的二十二碳六烯酸比二十碳五烯酸。当在相同的模型中将总胆固醇与Omega-3指数进行比较时，后者与这些结果显著相关，但前者则不然。随访时间相对较短，一次性暴露评估。较高的欧米茄-3指数与心血管疾病和全因死亡率的风险降低相关。
The extent to which omega-3 fatty acid status is related to risk for death from any cause and for incident cardiovascular disease (CVD) remains controversial. To examine these associations in the Framingham Heart Study. Prospective and observational. Framingham Heart Study Offspring cohort. The exposure marker was red blood cell levels of eicosapentaenoic and docosahexaenoic acids (the Omega-3 Index) measured at baseline. Outcomes included mortality (total, CVD, cancer, and other) and total CVD events in participants free of CVD at baseline. Follow-up was for a median of 7.3 years. Cox proportional hazards models were adjusted for 18 variables (demographic, clinical status, therapeutic, and CVD risk factors). Among the 2500 participants (mean age 66 years, 54% women), there were 350 deaths (58 from CVD, 146 from cancer, 128 from other known causes, and 18 from unknown causes). There were 245 CVD events. In multivariable-adjusted analyses, a higher Omega-3 Index was associated with significantly lower risks (P-values for trends across quintiles) for total mortality (P = .02), for non-CVD and non-cancer mortality (P = .009), and for total CVD events (P = .008). Those in the highest (>6.8%) compared to those in the lowest Omega-3 Index quintiles (<4.2%) had a 34% lower risk for death from any cause and 39% lower risk for incident CVD. These associations were generally stronger for docosahexaenoic acid than for eicosapentaenoic acid. When total cholesterol was compared with the Omega-3 Index in the same models, the latter was significantly related with these outcomes, but the former was not. Relatively short follow-up time and one-time exposure assessment. A higher Omega-3 Index was associated with reduced risk of both CVD and allcause mortality.
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影响因子：
5.4
作者：
Flock MR;Skulas-Ray AC;Harris WS;Etherton TD;Fleming JA;Kris-Etherton PM
通讯作者：
Kris-Etherton PM
影响因子：
5.8
作者：
Harris, William S.
通讯作者：
Harris, William S.
影响因子：
5.3
作者：
Cawood, Abbie L.;Ding, Ren;Calder, Philip C.
通讯作者：
Calder, Philip C.
DOI：
10.1136/bmj.e6698
发表时间：
2012-10-30
期刊：
BMJ (Clinical research ed.)
影响因子：
--
作者：
Chowdhury R;Stevens S;Gorman D;Pan A;Warnakula S;Chowdhury S;Ward H;Johnson L;Crowe F;Hu FB;Franco OH
通讯作者：
Franco OH
影响因子：
39.3
作者：
Eussen, Simone R. B. M.;Geleijnse, Johanna M.;Kromhout, Daan
通讯作者：
Kromhout, Daan