Axial-shear strain imaging for differentiating benign and malignant breast masses.
Axial-shear strain imaging for differentiating benign and malignant breast masses.
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DOI：
10.1016/j.ultrasmedbio.2010.07.008
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发表时间：
2010-11
影响因子：
2.9
通讯作者：
Burnside, Elizabeth S.
中科院分区：
文献类型：
--
作者：
Xu, Haiyan;Rao, Min;Varghese, Tomy;Sommer, Amy;Baker, Sara;Hall, Timothy J.;Sisney, Gale A.;Burnside, Elizabeth S.
轴向应变成像已被用于乳房肿块的表征超过十年，然而，另一个重要的功能，即乳房肿块周围的剪切应变分布最近才被使用。在本文中，我们研究的可行性，利用在体内轴向剪切应变成像区分良性和恶性乳腺肿块。在威斯康星州大学乳腺癌中心，使用西门子SONOLINE Antares实时临床扫描仪，使用VFX 13-5线性阵列传感器对41名患者采集射频数据。使用高达10%的变形的徒手触诊被用来生成轴向应变和轴向剪切应变图像，使用二维互相关算法从射频数据循环。轴向剪切应变面积归一化为病变大小，应用应变和病变应变对比度被用作区分良性和恶性肿块的特征。8例恶性肿瘤患者和33例纤维腺瘤患者的标准化轴向剪切应变面积特征估计被用来证明其潜在的病变分化。活检结果被认为是比较的诊断标准。我们的研究结果表明，与良性肿块如纤维腺瘤相比，恶性肿瘤的标准化轴向剪切应变面积明显更大。轴向剪切应变像素值大于规定的阈值，仅包括那些相关系数值大于0.75，被覆盖在相应的B型图像，以帮助诊断。归一化面积特征的散点图证明了开发线性分类器区分良性和恶性肿块的可行性。利用标准化轴向剪切应变面积特征的受试者操作特征曲线下的面积为0.996，表明该特征具有无创区分良性和恶性乳腺肿块的潜力。
Axial strain imaging has been utilized for the characterization of breast masses for over a decade; however, another important feature namely the shear strain distribution around breast masses has only recently been used. In this paper, we examine the feasibility of utilizing in-vivo axial-shear strain imaging for differentiating benign from malignant breast masses. Radiofrequency data was acquired using a VFX 13-5 linear array transducer on 41 patients using a Siemens SONOLINE Antares real-time clinical scanner at the University of Wisconsin Breast Cancer Center. Free-hand palpation using deformations of up to 10% was utilized to generate axial strain and axial-shear strain images using a two-dimensional cross-correlation algorithm from the radiofrequency data loops. Axial-shear strain areas normalized to the lesion size, applied strain and lesion strain contrast was utilized as a feature for differentiating benign from malignant masses. The normalized axial-shear strain area feature estimated on 8 patients with malignant tumors and 33 patients with fibroadenomas was utilized to demonstrate its potential for lesion differentiation. Biopsy results were considered the diagnostic standard for comparison. Our results indicate that the normalized axial-shear strain area is significantly larger for malignant tumors when compared to benign masses such as fibroadenomas. Axial-shear strain pixel values greater than a specified threshold, including only those with correlation coefficient values greater than 0.75, were overlaid on the corresponding B-mode image to aid in diagnosis. A scatter plot of the normalized area feature demonstrates the feasibility of developing a linear classifier to differentiate benign from malignant masses. The area under the receiver operator characteristic curve utilizing the normalized axial-shear strain area feature was 0.996, demonstrating the potential of this feature to noninvasively differentiate between benign and malignant breast masses.
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影响因子：
19.7
作者：
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通讯作者：
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