A four-generation family transmission chain of COVID-19 along the China-Myanmar border in October to November 2021.
A four-generation family transmission chain of COVID-19 along the China-Myanmar border in October to November 2021.
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2021 年 10 月至 2021 年 11 月中缅边境沿线的 COVID-19 四代家庭传播链
DOI：
10.3389/fpubh.2022.1004817
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发表时间：
2022
影响因子：
5.2
通讯作者：
Shui, Tiejun
中科院分区：
文献类型：
--
作者：
Yan, Xiangyu;Xiao, Wei;Zhou, Saipeng;Wang, Xuechun;Wang, ZeKun;Zhao, Mingchen;Li, Tao;Jia, Zhongwei;Zhang, Bo;Shui, Tiejun
境外输入病例和家庭内传播是疫情防控的重点和难点，也给边境地区防控带来挑战。然而，中国边境地区尚未报告由外国输入病例引起的家庭传播。本研究旨在揭示2021年10月至11月中缅边境疫情期间与缅甸难民接触导致的COVID-19家庭聚集性传播链。疫情期间，对新冠肺炎确诊患者及其日常活动密切接触者进行了详细的流行病学调查。患者立即被转移到指定医院接受治疗和隔离，密切接触者被集中隔离。定期进行核酸检测和新冠病毒抗体检测。在中缅边境发现了明显的四代家族聚集性传播，涉及5名COVID-19患者。指示病例（患者A）是在工作期间与缅甸难民隔着边境围栏进行简短交谈而感染的。患者的妻子（患者B）和9个月大的女儿（患者C）是因与患者日常接触而感染的第二代病例。他2岁的女儿（D患者）是在隔离期间被母亲和姐姐感染的第三代患者，在B患者和C患者被确诊并送往医院后，将病毒传染给了照顾她的祖母（E患者，第四代患者）。家庭二次侵染率为80.0%，平均潜伏期为4 d，产生时间为3 d。该家族942例密切接触者医学观察期间IgM抗体阳性10例（1.1%）。73.9%（696/942）的人IgG抗体阳性，8.3%（58/696）的人IgG抗体水平超过20 S/CO（样品光密度/试剂截止值）。这一典型的传播链表明，加强边境地区防控，探索更有效的隔离点儿童看护方法至关重要。
Foreign imported patients and within-household transmission have been the focus and difficulty of coronavirus disease 2019 (COVID-19) prevention and control, which has also posed challenges to border areas' management. However, household transmission caused by foreign imported cases has not been reported in China's border areas. This study aimed to reveal a clear family clustering transmission chain of COVID-19 caused by contact with Myanmar refugees along the China–Myanmar border during an outbreak in October to November 2021. During the outbreak, detailed epidemiological investigations were conducted on confirmed patients with COVID-19 and their close contacts in daily activities. Patients were immediately transported to a designated hospital for treatment and quarantine, and their close contacts were quarantined at designated sites. Regular nucleic acid testing and SARS-CoV-2 antibody testing were provided to them. A clear four-generation family clustering transmission involving five patients with COVID-19 was found along the China–Myanmar border. The index case (Patient A) was infected by brief conversations with Myanmar refugees across border fences during work. His wife (Patient B) and 9-month-old daughter (Patient C) were second-generation cases infected by daily contact with him. His 2-year-old daughter (Patient D) was the third-generation case infected by her mother and sister during quarantine in the same room and then transmitted the virus to her grandmother (Patient E, the fourth-generation case) who looked after her after Patients B and C were diagnosed and transported to the hospital. The household secondary attack rate was 80.0%, the average latent period was 4 days, and the generation time was 3 days. Ten of 942 close contacts (1.1%) of this family had positive IgM antibody during the medical observation period. In total 73.9% (696/942) of them were positive for IgG antibody and 8.3% (58/696) had IgG levels over 20 S/CO (optical density of the sample/cut-off value of the reagent). This typical transmission chain indicated that it is essential to strengthen COVID-19 prevention and control in border areas, and explore more effective children care approaches in quarantine sites.
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影响因子：
13.2
作者：
Wang X;Yang L;Jiang T;Zhang B;Wang S;Wu X;Wang T;Li Y;Liu M;Peng Q;Zhang W
通讯作者：
Zhang W
影响因子：
11.8
作者：
Tang, Song;Mao, Yixin;Shi, Xiaoming
通讯作者：
Shi, Xiaoming
DOI：
10.3390/ijerph182010734
发表时间：
2021-10-13
影响因子：
--
作者：
Liu Y;Yang B;Liu L;Jilili M;Yang A
通讯作者：
Yang A
影响因子：
4.7
作者：
Zhou L;Nie K;Zhao H;Zhao X;Ye B;Wang J;Chen C;Wang H;Di J;Li J;Li C;Chen Z;Ren R;Niu P;Chen H;Chen T;Wang Y;Li L;Han B;A R;Chen S;Li D;Li D;Jin C;Zhang X;Liu J;Xu C;Yao Y;Feng Y;Li Z;Zhang B;Song Y;Hao P;Zhang Y;Li H;Li Q;Gao GF;Shi G;Xu W
通讯作者：
Xu W
DOI：
10.1016/s1473-3099(21)00648-4
发表时间：
2022-03
期刊：
The Lancet. Infectious diseases
影响因子：
--
作者：
Singanayagam A;Hakki S;Dunning J;Madon KJ;Crone MA;Koycheva A;Derqui-Fernandez N;Barnett JL;Whitfield MG;Varro R;Charlett A;Kundu R;Fenn J;Cutajar J;Quinn V;Conibear E;Barclay W;Freemont PS;Taylor GP;Ahmad S;Zambon M;Ferguson NM;Lalvani A;ATACCC Study Investigators
通讯作者：
ATACCC Study Investigators