Multi-Country analysis of palm oil consumption and cardiovascular disease mortality for countries at different stages of economic development: 1980-1997.
Multi-Country analysis of palm oil consumption and cardiovascular disease mortality for countries at different stages of economic development: 1980-1997.
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DOI：
10.1186/1744-8603-7-45
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发表时间：
2011-12-16
影响因子：
10.8
通讯作者：
Goldhaber-Fiebert JD
中科院分区：
文献类型：
--
作者：
Chen BK;Seligman B;Farquhar JW;Goldhaber-Fiebert JD
心血管疾病在全球疾病负担中所占份额越来越大。人们担心，棕榈油消费量的增加可能会加剧缺血性心脏病（IHD）和中风的死亡率，特别是在发展中国家，棕榈油是饱和脂肪的主要营养来源。该研究分析了1980-1997年的国家级数据，这些数据来自世界卫生组织的死亡率数据库、美国农业部的国际估计和世界银行（23个国家的234个年度观察结果）。结果包括50岁及以上成人IHD和卒中的死亡率。预测因素包括棕榈油和卷烟的人均消费量和人均国内生产总值以及棕榈油消费量与国家经济发展水平之间的相互作用。分析采用线性面板回归法检查了国家一级结果随时间的变化，其中包括国家一级固定效应、人口加权和按国家聚类的稳健标准误。敏感性分析包括进一步调整其他主要饮食来源的饱和脂肪。在发展中国家，每年人均棕榈油消费量每增加1千克，IHD死亡率增加68/100，000（95%CI [21-115]），而在类似环境中，中风死亡率增加19/100，000（95%CI [-12-49]），但不显著。对于历史上的高收入国家，棕榈油消费导致的IHD和中风死亡率的变化较小（IHD：每10万人中有17例死亡（95% CI [5.3-29]）;中风：每10万人中有5.1例死亡（95% CI [-1.2-11.0]））。包括牛肉、猪肉、鸡肉、椰子油、牛奶奶酪和黄油在内的其他主要饱和脂肪来源并没有实质性改变棕榈油与发展中国家IHD死亡率之间的差异性较高关系。棕榈油消费量的增加与发展中国家IHD死亡率较高有关。棕榈油消费是与旨在减少心血管疾病负担的政策相关的饱和脂肪来源。
Cardiovascular diseases represent an increasing share of the global disease burden. There is concern that increased consumption of palm oil could exacerbate mortality from ischemic heart disease (IHD) and stroke, particularly in developing countries where it represents a major nutritional source of saturated fat. The study analyzed country-level data from 1980-1997 derived from the World Health Organization's Mortality Database, U.S. Department of Agriculture international estimates, and the World Bank (234 annual observations; 23 countries). Outcomes included mortality from IHD and stroke for adults aged 50 and older. Predictors included per-capita consumption of palm oil and cigarettes and per-capita Gross Domestic Product as well as time trends and an interaction between palm oil consumption and country economic development level. Analyses examined changes in country-level outcomes over time employing linear panel regressions with country-level fixed effects, population weighting, and robust standard errors clustered by country. Sensitivity analyses included further adjustment for other major dietary sources of saturated fat. In developing countries, for every additional kilogram of palm oil consumed per-capita annually, IHD mortality rates increased by 68 deaths per 100,000 (95% CI [21-115]), whereas, in similar settings, stroke mortality rates increased by 19 deaths per 100,000 (95% CI [-12-49]) but were not significant. For historically high-income countries, changes in IHD and stroke mortality rates from palm oil consumption were smaller (IHD: 17 deaths per 100,000 (95% CI [5.3-29]); stroke: 5.1 deaths per 100,000 (95% CI [-1.2-11.0])). Inclusion of other major saturated fat sources including beef, pork, chicken, coconut oil, milk cheese, and butter did not substantially change the differentially higher relationship between palm oil and IHD mortality in developing countries. Increased palm oil consumption is related to higher IHD mortality rates in developing countries. Palm oil consumption represents a saturated fat source relevant for policies aimed at reducing cardiovascular disease burdens.
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影响因子：
37.8
作者：
Wilson, PWF;D'Agostino, RB;Kannel, WB
通讯作者：
Kannel, WB
影响因子：
39.2
作者：
KANNEL, WB;CASTELLI, WP;MCNAMARA, PM
通讯作者：
MCNAMARA, PM
影响因子：
7.1
作者：
Vega-Lopez, Sonia;Ausman, Lynne M.;Lichtenstein, Alice H.
通讯作者：
Lichtenstein, Alice H.
DOI：
10.1097/00005768-199711000-00006
发表时间：
1997-11-01
期刊：
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
影响因子：
--
作者：
Nicolosi, RJ;Rogers, EJ
通讯作者：
Rogers, EJ
影响因子：
168.9
作者：
Strong, K;Mathers, C;Beaglehole, R
通讯作者：
Beaglehole, R