Steroids from the aerial parts of Leonurus japonicus

Steroids from the aerial parts of Leonurus japonicus
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益母草地上部分的类固醇

DOI:
10.1016/j.phytol.2015.04.027
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发表时间:
2015-06
影响因子:
1.7
通讯作者:
Liang Xiong
Liang Xiong
中科院分区:
生物学4区
文献类型:
--
作者:
Xiao-fang Xie;Li Guo;Zhao-hua Liu;Liang Xiong

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Two new steroids, (24S)-stigmast-4,28-diene-24-ol-3-one (1) and mono-β-sitosteryl azelate (2), along with ten known analogues (3–12), were isolated from the ethanolic extract ofLeonurus japonicusHoutt. Their structures were elucidated by spectroscopic and chemical methods. The absolute configuration of1was confirmed by single crystal X-ray crystallographic analysis using anomalous scattering of Cu Kα radiation. Compounds3,4, and9showed significant inhibitory activities against ADP-induced platelet aggregation, while compound1had a weak cytotoxic activity against acute myeloid leukemia cell line MV4-11.
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