Developing a model for estimating the activity of colonic microbes after intestinal surgeries.
Developing a model for estimating the activity of colonic microbes after intestinal surgeries.
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DOI：
10.1371/journal.pone.0253542
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发表时间：
2021
期刊：
影响因子：
3.7
通讯作者：
Krajmalnik-Brown R
中科院分区：
文献类型：
--
作者：
Marcus A;Davis TL;Rittmann BE;DiBaise JK;Carnero EA;Corbin K;Smith SR;Krajmalnik-Brown R
当广泛的小肠切除术或旁路手术等手术干预降低上消化道（GI）营养吸收效率时，大肠在能量恢复中起补偿作用。虽然已知结肠中的微生物在恢复能量方面起着至关重要的作用，但它们的贡献在小肠切除术中仍有待鉴定和量化。我们开发了一个数学模型，将上消化道和下消化道的营养吸收分为两个步骤。首先，我们描述了小肠切除对回盲输出（ICO）的影响，回盲输出进入结肠并为微生物提供食物。其次，我们描述了能量回收的结肠的微生物通过短链脂肪酸（SCFA）的生产。我们通过对生理正常受试者和接受小肠切除术的受试者的临床数据进行最小二乘回归分析来获得模型参数。对于肠道完整的受试者，我们的模型提供了一个代谢能值，与传统的阿特沃特系数很好地吻合。随着小肠的去除，生理吸收效率降低，代谢能降低。同时，小肠生理吸收的低效率部分地通过结肠中微生物从蛋白质和碳水化合物产生短链脂肪酸（SCFA）来补偿。当整个小肠被移除时，结肠恢复了总能量摄入的一半以上。与此同时，吸收的能量的质量发生了变化，因为微生物来源的SCFAs，而不是食物的原始成分，成为吸收能量的主要形式。这里开发的数学模型为描述临床干预对结肠微生物的影响提供了一个重要的框架。
The large intestine provides a compensatory role in energy recovery when surgical interventions such as extensive small intestinal resections or bypass operations lower the efficiency of nutrient absorption in the upper gastrointestinal (GI) tract. While microorganisms in the colon are known to play vital roles in recovering energy, their contributions remain to be qualified and quantified in the small intestine resection. We develop a mathematical model that links nutrient absorption in the upper and lower GI tract in two steps. First, we describe the effects of small intestine resection on the ileocecal output (ICO), which enters the colon and provides food for microbes. Second, we describe energy recovered by the colon’s microorganisms via short-chain fatty acid (SCFA) production. We obtain model parameters by performing a least-squares regression analysis on clinical data for subjects with normal physiology and those who had undergone small intestine resection. For subjects with their intestines intact, our model provided a metabolizable energy value that aligns well with the traditional Atwater coefficients. With removal of the small intestine, physiological absorption became less efficient, and the metabolizable energy decreased. In parallel, the inefficiencies in physiological absorption by the small intestine are partly compensated by production of short-chain fatty acids (SCFA) from proteins and carbohydrates by microorganisms in the colon. The colon recovered more than half of the gross energy intake when the entire small intestine was removed. Meanwhile, the quality of energy absorbed changed, because microbe-derived SCFAs, not the original components of food, become the dominant form of absorbed energy. The mathematical model developed here provides an important framework for describing the effect of clinical interventions on the colon’s microorganisms.
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影响因子：
3.7
作者：
Bax ML;Buffière C;Hafnaoui N;Gaudichon C;Savary-Auzeloux I;Dardevet D;Santé-Lhoutellier V;Rémond D
通讯作者：
Rémond D
DOI：
10.1038/s41575-020-0341-5
发表时间：
2020-11
期刊：
Nature reviews. Gastroenterology & hepatology
影响因子：
--
作者：
Gupta A;Osadchiy V;Mayer EA
通讯作者：
Mayer EA
影响因子：
5.1
作者：
Kettle, Helen;Louis, Petra;Flint, Harry J.
通讯作者：
Flint, Harry J.
影响因子：
24.5
作者：
CHACKO, A;CUMMINGS, JH
通讯作者：
CUMMINGS, JH
DOI：
10.1152/ajpendo.00559.2009
发表时间：
2010-03-01
影响因子：
5.1
作者：
Hall, Kevin D.
通讯作者：
Hall, Kevin D.