An artificial tendon with durable muscle interface.
An artificial tendon with durable muscle interface.
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DOI：
10.1002/jor.20971
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发表时间：
2010-02
影响因子：
2.8
通讯作者：
Juncosa-Melvin, Natalia
中科院分区：
文献类型：
--
作者：
Melvin, Alan;Litsky, Alan;Mayerson, Joel;Witte, David;Melvin, David;Juncosa-Melvin, Natalia
能够将有力收缩的肌肉永久地固定到骨锚或任何完全惰性的假体的联接机构将满足矫形外科学中的迫切需要。我们的团队开发了OrthoCoupler™器械来满足这些需求。本研究的目的是在山羊半腱肌腱模型中测试OrthoCoupler的体外和体内性能。对于体外评估，对40个样本进行了疲劳测试，在10个载荷水平下循环，每个载荷水平n=4。为了进行体内评价，在8只山羊中双侧切除半腱肌腱。左侧使用OrthoCoupler重新连接，右侧使用Krackow缝线和#5编织聚酯缝线重新连接。术后60天采集标本，并分配用于生物力学和组织学。在体外试验中，该装置的疲劳强度是半腱肌收缩力的几倍。体内器械的构建等同于两种体外器械，提供了额外的安全系数。在尸检时的强度测试中，缝线对照在120.5 ± 68.3 N时被拉出，而每个OrthoCoupler在肌肉撕裂后仍保持在298± 111.3 N（平均值±标准差）（p<0.0003）。在愈合过程中产生的纤维-肌肉复合物仍然完好的情况下达到肌肉撕裂强度。该技术可能对肿瘤学、关节翻修术、肌腱转移和运动损伤重建中的骨科挑战具有价值。
A coupling mechanism that can permanently fix a forcefully contracting muscle to a bone anchor or any totally inert prosthesis would meet a serious need in orthopaedics. Our group developed the OrthoCoupler™ device to satisfy these demands. The objective of this study was to test OrthoCoupler’s performance in vitro and in vivo in the goat semitendinosus tendon model. For in vitro evaluation, 40 samples were fatigue-tested, cycling at 10 load levels, n=4 each. For in vivo evaluation, the semitendinosus tendon was removed bilaterally in 8 goats. Left sides were reattached with an OrthoCoupler, and right sides were reattached using the Krackow stitch with #5 braided polyester sutures. Specimens were harvested 60 days post-surgery and assigned for biomechanics and histology. Fatigue strength of the devices in vitro was several times the contractile force of the semitendinosus muscle. The in vivo devices were built equivalent to two of the in vitro devices, providing an additional safety factor. In strength testing at necropsy, suture controls pulled out at 120.5 ± 68.3 N, whereas each OrthoCoupler was still holding after the muscle tore, remotely, at 298±111.3N (mean ± SD)(p<0.0003). Muscle tear strength was reached with the fiber-muscle composite produced in healing still soundly intact. This technology may be of value for orthopaedic challenges in oncology, revision arthroplasty, tendon transfer, and sports-injury reconstruction.
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DOI：
10.3109/17453679909000997
发表时间：
1999-10-01
期刊：
ACTA ORTHOPAEDICA SCANDINAVICA
影响因子：
--
作者：
Ozaki, T;Kunisada, T;Inoue, H
通讯作者：
Inoue, H
影响因子：
2.4
作者：
Trumble, DR;Melvin, DB;Magovern, JA
通讯作者：
Magovern, JA
影响因子：
4.2
作者：
Melvin, DB;Klosterman, B;Clarson, SJ
通讯作者：
Clarson, SJ
DOI：
10.1302/0301-620x.67b2.3980547
发表时间：
1985-01-01
影响因子：
--
作者：
HOWARD, CB;MCKIBBIN, B;RALIS, ZA
通讯作者：
RALIS, ZA
影响因子：
1.8
作者：
Panagiotopoulos, Elias C.;Kallivokas, Alkiviadis G.;Mouzakis, Dionysios E.
通讯作者：
Mouzakis, Dionysios E.