Cellular senescence in ageing: from mechanisms to therapeutic opportunities.
Cellular senescence in ageing: from mechanisms to therapeutic opportunities.
复制标题
衰老中的细胞衰老：从机制到治疗机会。
DOI：
10.1038/s41580-020-00314-w
复制
发表时间：
2021-03
期刊：
影响因子：
--
通讯作者：
d'Adda di Fagagna F
中科院分区：
文献类型：
--
作者：
Di Micco R;Krizhanovsky V;Baker D;d'Adda di Fagagna F
细胞衰老于 1961 年首次在体外被描述，现已成为生物技术公司关注的焦点，这些公司致力于通过细胞衰老来改善多种人类状况。细胞衰老的显着特征是永久性增殖停滞，是响应内源性和外源性应激而发生的，包括端粒功能障碍、癌基因激活和持续性 DNA 损伤。细胞衰老也可以是发生在包括胚胎发育在内的多种生物过程中的受控程序。衰老细胞的外在活动与衰老相关的分泌表型的激活广泛相关，放大了细胞内在增殖停滞的影响，并导致组织再生受损、慢性年龄相关疾病和机体衰老。这篇综述讨论了细胞衰老建立和衰老相关分泌表型诱导的机制和调节剂，并概述了细胞衰老作为通过衰老和衰老相关疾病的衰老和衰老相关疾病的衰老和衰老疗法干预的新兴机会。
Cellular senescence, first described in vitro in 1961, has become a focus for biotech companies that target it to ameliorate a variety of human conditions. Eminently characterized by a permanent proliferation arrest, cellular senescence occurs in response to endogenous and exogenous stresses, including telomere dysfunction, oncogene activation and persistent DNA damage. Cellular senescence can also be a controlled programme occurring in diverse biological processes, including embryonic development. Senescent cell extrinsic activities, broadly related to the activation of a senescence-associated secretory phenotype, amplify the impact of cell-intrinsic proliferative arrest and contribute to impaired tissue regeneration, chronic age-associated diseases and organismal ageing. This Review discusses the mechanisms and modulators of cellular senescence establishment and induction of a senescence-associated secretory phenotype, and provides an overview of cellular senescence as an emerging opportunity to intervene through senolytic and senomorphic therapies in ageing and ageing-associated diseases.
登录
查看更多内容
影响因子：
64.8
作者：
Bartkova, Jirina;Rezaei, Nousin;Gorgoulis, Vassilis G.
通讯作者：
Gorgoulis, Vassilis G.
影响因子：
7.8
作者：
Benetos A;Kark JD;Susser E;Kimura M;Sinnreich R;Chen W;Steenstrup T;Christensen K;Herbig U;von Bornemann Hjelmborg J;Srinivasan SR;Berenson GS;Labat C;Aviv A
通讯作者：
Aviv A
影响因子：
64.8
作者：
Baker DJ;Childs BG;Durik M;Wijers ME;Sieben CJ;Zhong J;Saltness RA;Jeganathan KB;Verzosa GC;Pezeshki A;Khazaie K;Miller JD;van Deursen JM
通讯作者：
van Deursen JM
DOI：
10.1083/jcb.201608026
发表时间：
2016-11-07
期刊：
The Journal of cell biology
影响因子：
--
作者：
Aird KM;Iwasaki O;Kossenkov AV;Tanizawa H;Fatkhutdinov N;Bitler BG;Le L;Alicea G;Yang TL;Johnson FB;Noma KI;Zhang R
通讯作者：
Zhang R
影响因子：
9
作者：
通讯作者：
--