Tracking and fixed ranking of leukocyte telomere length across the adult life course.
Tracking and fixed ranking of leukocyte telomere length across the adult life course.
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DOI：
10.1111/acel.12086
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发表时间：
2013-08
期刊：
影响因子：
7.8
通讯作者：
Aviv A
中科院分区：
文献类型：
--
作者：
Benetos A;Kark JD;Susser E;Kimura M;Sinnreich R;Chen W;Steenstrup T;Christensen K;Herbig U;von Bornemann Hjelmborg J;Srinivasan SR;Berenson GS;Labat C;Aviv A
短白细胞端粒长度（LTL）与成人动脉粥样硬化和老年人生存率降低有关。LTL动态是由出生时的LTL定义的，这是高度可变的，其后的年龄依赖性损耗，这在生命的前20年是快速的。我们研究了成年期年龄依赖性LTL损耗是否会显著影响个体的LTL排名（例如，长或短的LTL）。我们在4项纵向研究中测量了1156名参与者平均间隔12年捐赠的样本中的LTL。我们观察到基线和随访LTL之间的相关性为0.91-0.96。按十分位数对个体进行排序显示，94.1%（95%置信区间为92.6-95.4%）的个体显示随着时间的推移没有排名变化或变化1个十分位数。我们的结论是，在成年人中，LTL几乎是锚定到一个给定的排名随着时间的推移。因此，LTL与动脉粥样硬化和长寿的联系似乎在生命早期就建立起来了。成年期的生活方式及其改变不太可能对LTL排名产生重大影响。
Short leukocyte telomere length (LTL) is associated with atherosclerosis in adults and diminished survival in the elderly. LTL dynamics are defined by LTL at birth, which is highly variable, and its age-dependent attrition thereafter, which is rapid during the first 20 years of life. We examined whether age-dependent LTL attrition during adulthood can substantially affect individuals’ LTL ranking (e.g., longer or shorter LTL) in relation to their peers. We measured LTL in samples donated 12 years apart on average by 1156 participants in four longitudinal studies. We observed correlations of 0.91–0.96 between baseline and follow-up LTLs. Ranking individuals by deciles revealed that 94.1% (95% confidence interval of 92.6–95.4%) showed no rank change or a 1 decile change over time. We conclude that in adults, LTL is virtually anchored to a given rank with the passage of time. Accordingly, the links of LTL with atherosclerosis and longevity appear to be established early in life. It is unlikely that lifestyle and its modification during adulthood exert a major impact on LTL ranking.
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影响因子：
3.7
作者：
Farzaneh-Far R;Lin J;Epel E;Lapham K;Blackburn E;Whooley MA
通讯作者：
Whooley MA
影响因子：
4.5
作者：
Nordfjall, Katarina;Svenson, Ulrika;Norrback, Karl-Fredrik;Adolfsson, Rolf;Lenner, Per;Roos, Goran
通讯作者：
Roos, Goran
影响因子：
4.5
作者：
Aubert G;Baerlocher GM;Vulto I;Poon SS;Lansdorp PM
通讯作者：
Lansdorp PM
影响因子：
7.8
作者：
Mirabello L;Huang WY;Wong JY;Chatterjee N;Reding D;Crawford ED;De Vivo I;Hayes RB;Savage SA
通讯作者：
Savage SA
DOI：
10.1016/j.mrfmmm.2011.05.001
发表时间：
2012-02-01
影响因子：
2.3
作者：
Aviv, Abraham
通讯作者：
Aviv, Abraham