MiR-181a regulates lipid metabolism via IDH1.
MiR-181a regulates lipid metabolism via IDH1.
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MiR-181a 通过 IDH1 调节脂质代谢
DOI：
10.1038/srep08801
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发表时间：
2015-03-05
影响因子：
4.6
通讯作者：
Wu M
中科院分区：
文献类型：
--
作者：
Chu B;Wu T;Miao L;Mei Y;Wu M
脂质代谢对细胞能量平衡很重要。过多的细胞脂质积累与各种人类疾病如肥胖、心血管疾病甚至癌症有关。研究发现，miR-181 a是调节T淋巴细胞分化、血管发育和小脑神经退行性变的重要调节因子。本文报道了miR-181 a在调节脂质代谢中的新功能。MiR-181 a能够靶向异柠檬酸脱氢酶1（IDH 1），一种TCA循环中的代谢酶。通过靶向IDH 1，miR-181 a降低参与脂质合成的基因的表达，并增加参与β-氧化的基因的表达，从而抑制脂质积累。miR-181 a转基因小鼠与其野生型同窝小鼠相比显示出较低的体重，此外，miR-181 a转基因小鼠表现出较少的脂质蓄积。总之，这些发现揭示了一种新的miR-181 a-IDH 1轴，该轴在调节脂质代谢中具有重要作用，并暗示miR-181 a是脂质代谢紊乱的潜在治疗靶点。
Lipid metabolism is important for cellular energy homeostasis. Excessive cellular lipid accumulation is associated with various human diseases such as obesity, cardiovascular disease or even cancer. It has been recognized that miR-181a is an important modulator in regulating T lymphocyte differentiation, vascular development and cerebellar neurodegeneration. Here we reports a novel function of miR-181a in the regulation of lipid metabolism. MiR-181a is able to target isocitrate dehydrogenase 1 (IDH1), a metabolic enzyme in TCA cycle. Via targeting IDH1, miR-181a decreases expression of genes involved in lipid synthesis and increases expression of genes involved in β-oxidation, thereafter inhibiting lipid accumulation. MiR-181a transgenic mice show a lower body weight as compared with their wild-type littermates and moreover, miR-181a transgenic mice exhibit less lipid accumulation. Collectively, these findings uncover a novel miR-181a-IDH1 axis that has an important role in regulating lipid metabolism and implicate miR-181a as a potential therapeutic target for lipid metabolism disorders.
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DOI：
10.1126/science.1189123
发表时间：
2010-06-18
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Najafi-Shoushtari SH;Kristo F;Li Y;Shioda T;Cohen DE;Gerszten RE;Näär AM
通讯作者：
Näär AM
影响因子：
50.3
作者：
Figueroa ME;Abdel-Wahab O;Lu C;Ward PS;Patel J;Shih A;Li Y;Bhagwat N;Vasanthakumar A;Fernandez HF;Tallman MS;Sun Z;Wolniak K;Peeters JK;Liu W;Choe SE;Fantin VR;Paietta E;Löwenberg B;Licht JD;Godley LA;Delwel R;Valk PJ;Thompson CB;Levine RL;Melnick A
通讯作者：
Melnick A
影响因子：
15.9
作者：
Taylor, Molly A.;Sossey-Alaoui, Khalid;Schiemann, William P.
通讯作者：
Schiemann, William P.
DOI：
10.1073/pnas.1005191107
发表时间：
2010-07-06
影响因子：
11.1
作者：
Marquart, Tyler J.;Allen, Ryan M.;Baldan, Angel
通讯作者：
Baldan, Angel
影响因子：
6.5
作者：
Shechter, I;Dai, PH;Guan, GM
通讯作者：
Guan, GM